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Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Madrigal Pharmaceuticals (NASDAQ: MDGL) Reports Impressive Topline Results from Phase 3 Trial of Resmetirom to Treat NASH and Liver Fibrosis

Madrigal Pharmaceuticals, Inc. (NASDAQ: MDGL) is engaged as a clinical-stage biopharmaceutical company, which is focused on the research and development of innovative therapies to treat nonalcoholic steatohepatitis (NASH), a liver disease with a significant unmet medical need. Shares of the biopharma company are skyrocketing 251% through late trading on Monday, December 19, 2022. Over the past three months, Madrigal Pharmaceuticals has seen average daily volume of 313,890 shares. However, volume of 7.17 million shares or dollar volume of around $1.56 billion, has already exchanged hands through late trading.

Shares of Madrigal Pharmaceuticals are surging after the company released positive topline results from its Phase 3 MAESTRO-NASH clinical trial of Resmetirom for the treatment of NASH and liver fibrosis. During the Phase 3 trial, the company conducted a 52-week serial liver biopsy study in over 950 patients. Resmetirom was found to achieve both primary and secondary endpoints with both its daily oral doses of 80 mg and 100 mg, relative to the placebo group.

The MAESTRO-NASH Phase 3 trial will continue to provide enrolled patients with therapy after the 52nd week of the clinical trial, for a total of 54 months to accrue hepatic clinical outcome events including histologic conversion to cirrhosis and hepatic decompensation events. At the beginning of the trial, baseline liver biopsy fibrosis scores were not good, with 84% NAS > 5 based on independent primary glass slide reads.

After 52 weeks of treatment, a second biopsy was conducted to assess efficacy of the treatment. The results showed a statistically significant response at both the 80 mg and 100 mg doses. Secondary liver biopsy endpoints were met at both doses after a >2 point reduction in NAS with no worsening fibrosis, >2 point reduction in NAS with ?1-stage improvement in fibrosis, NASH resolution (>2 point reduction in NAS) with >1-stage improvement in fibrosis, and a 2-stage reduction in fibrosis without worsening of NAS. Resmetirom was safe and well-tolerated throughout the study, similar to the results from the previous Phase 2 & 3 data.

Becky Taub, M.D., Chief Medical Officer and President of Research & Development of Madrigal: “These pivotal Phase 3 results demonstrate the potential for resmetirom to help patients achieve improvement in both the underlying steatohepatitis that drives this disease and the resulting fibrosis that is associated with progression to cirrhosis and its complications. The topline data also reinforce our confidence in the safety and tolerability profile of resmetirom. We believe the Phase 3 MAESTRO clinical development program, including the MAESTRO-NAFLD-1 and MAESTRO-NAFLD-OLE safety clinical trials and the recently initiated MAESTRO-NASH-OUTCOMES clinical trial, provides a strong foundation for our new drug application (NDA) and the potential accelerated approval of resmetirom for the treatment of non-cirrhotic NASH with liver fibrosis.”

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

The post Madrigal Pharmaceuticals (NASDAQ: MDGL) Reports Impressive Topline Results from Phase 3 Trial of Resmetirom to Treat NASH and Liver Fibrosis appeared first on Spotlight Growth.

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