About Cabling Installation & Maintenance

Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Pliant Therapeutics (NASDAQ: PLRX) Reports Positive Phase 2 Clinical Trial Data of Bexotegrast in Treatment of Idiopathic Pulmonary Fibrosis

Pliant Therapeutics, Inc. (NASDAQ: PLRX) is engaged as a clinical-stage biopharmaceutical company, which is focused on the research and development of innovative therapies to treat fibrosis. Shares of the biopharma company are surging 52% through early trading on Monday, January 23, 2023. Over the past three months, Pliant Therapeutics has seen average daily volume of 405,880 shares. However, volume of 7.76 million shares or dollar volume of around $266.79 million, has already exchanged hands through early trading.

Shares of Pliant Therapeutics are rallying after the company announced positive interim data from its INTEGRIS-IPF Phase 2 clinical trial of bexotegrast in patients with idiopathic pulmonary fibrosis (IPF). The Phase 2 trial is a multi-national, randomized, double-blind, placebo-controlled trial, which was testing a dose of 320 mg of bexotegrast.

After an initial 12-weeks, interim data from the 320 mg dose group met its primary and secondary endpoints, which demonstrated the treatment was well tolerated and provided a favorable pharmacokinetic profile. The trial’s exploratory efficacy endpoints focused on charges in forced vital capacity (FVC), Quantitative Lung Fibrosis (QLF) imaging and biomarkers. At the 320 mg dose, bexotegrast was able to generate a statistically-significant average increase in FVC from the base at all timepoint. This shows the treatment has a strong effect on FVC percent predicted, QLF, and profibrotic biomarkers versus the placebo over the course of twelve weeks.

“Data from the INTEGRIS-IPF trial have far exceeded our expectations, supporting bexotegrast’s favorable safety profile and demonstrating a statistically significant treatment response on FVC at 320 mg,” said Éric Lefebvre, M.D., Chief Medical Officer at Pliant Therapeutics. “Additionally, we are extremely encouraged to see a consistent dose response on FVC, QLF and profibrotic biomarkers. We look forward to advancing bexotegrast into Phase 2b clinical development.”

Pilant Therapeutics says it will continue its Phase 2 clinical trial of bexotegrast and the 320 mg dosing group for at least 24 weeks. The next round of clinical data is estimated to be released during the second quarter of 2023. Furthermore, Pilant is planning to launch Phase 2b clinical trial of its drug candidate during mid-2023.

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

The post Pliant Therapeutics (NASDAQ: PLRX) Reports Positive Phase 2 Clinical Trial Data of Bexotegrast in Treatment of Idiopathic Pulmonary Fibrosis appeared first on Spotlight Growth.

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