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Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
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  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
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Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Benitec’s (NASDAQ: BNTC) IND for BB-301 Cleared by FDA: A Milestone for OPMD Treatment

Benitec Biopharma Inc. (NASDAQ: BNTC), a leader in gene therapy, has announced that the U.S. Food and Drug Administration (FDA) has approved its Investigational New Drug (IND) application for BB-301. This marks a significant development in the treatment of Oculopharyngeal Muscular Dystrophy-related Dysphagia (OPMD).

Benitec’s BB-301: First Potential Treatment for OPMD

Oculopharyngeal Muscular Dystrophy, a life-threatening genetic disorder, affects roughly 15,000 patients across the United States, Canada, Western Europe, and Israel. Patients suffering from OPMD lose the ability to swallow liquids and solids, which often leads to chronic malnutrition and even fatal aspiration pneumonia. Until now, there have been no approved therapeutic agents to treat this disorder. Benitec’s BB-301, a ‘silence and replace’ gene therapy, represents the first possible treatment for OPMD’s often debilitating and potentially fatal symptoms.

IND Clearance: A Milestone for Benitec

Jerel A. Banks, M.D., Ph.D., Executive Chairman and CEO of Benitec, hailed the FDA’s clearance of BB-301’s IND as a significant milestone for both OPMD patients and the company itself. He emphasized the importance of this breakthrough treatment in potentially addressing the severe symptoms of OPMD.

The Phase 1b/2a Clinical Study: Participants and Process

Participants from Benitec’s ongoing Natural History (NH) study will be eligible for the Phase 1b/2a clinical study of BB-301, following six months of baseline data collection. After undergoing a one-day dosing procedure, each study participant will be evaluated on various clinical and radiographic outcome measures, including objective assessments of swallowing safety and efficiency. Currently, 13 subjects are enrolled in the NH study, with the potential for each to transition to the Phase 1b/2a clinical dosing study for BB-301.

BB-301: A Unique Therapeutic Approach

BB-301 employs a novel silence-and-replace strategy, making use of a unique, single bifunctional construct. This construct promotes co-expression of both codon-optimized Poly-A Binding Protein Nuclear-1 (PABPN1) and two small inhibitory RNAs (siRNAs) against mutant PABPN1. The two siRNAs silence the expression of the faulty mutant PABPN1 while permitting the expression of a functional version of the protein. Benitec believes that this unique approach positions BB-301 optimally for the treatment of OPMD by halting mutant expression while providing a functional replacement protein.

As Benitec moves forward with the next stage of trials, the healthcare industry is eagerly awaiting the potential benefits this unique therapeutic approach could offer OPMD patients.

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

The post Benitec’s (NASDAQ: BNTC) IND for BB-301 Cleared by FDA: A Milestone for OPMD Treatment appeared first on Spotlight Growth.

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