About Cabling Installation & Maintenance

Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Black Diamond Therapeutics’ (NASDAQ: BDTX) BDTX-1535 Proves Promising for EGFR Mutated NSCLC and GBM

Black Diamond Therapeutics has announced encouraging initial data from a Phase 1 study of BDTX-1535, an investigational fourth-generation EGFR MasterKey inhibitor. The trial targets patients with non-small cell lung cancer (NSCLC) and glioblastoma multiforme (GBM) with acquired and intrinsic driver EGFR mutations.

Key Findings from the Phase 1 Study of BDTX-1535

The study showed clinical proof of BDTX-1535’s efficacy in NSCLC patients. Partial response, confirmed by RECIST 1.1, was observed in 5 out of 12 NSCLC patients treated with predicted therapeutic doses. Another patient showed unconfirmed partial response, while six others exhibited stable disease.

BDTX-1535 exhibited a favorable tolerability profile, supporting its exploration in NSCLC expansion cohorts. Anticipated updates on the GBM cohort from the Phase 1 dose escalation data are due in Q4 2023.

BDTX-1535 Phase 1 Study Design and Initial Results

This first-in-human open-label clinical trial of BDTX-1535 involved dose escalation, followed by dose expansion cohorts. The study assessed the safety, pharmacokinetics, and preliminary anti-tumor activity of BDTX-1535 in adult patients with advanced/metastatic NSCLC or recurrent GBM expressing EGFR alterations.

As of May 20, 2023, 51 patients had been treated with BDTX-1535, exhibiting a linear increase in exposure and a half-life of approximately 15 hours. The drug was well-tolerated by NSCLC and GBM patients, and the overall safety profile was consistent with the EGFR tyrosine kinase inhibitor (TKI) class of drugs.

Promising Results Spur Further Investigation

Based on the data gathered, Black Diamond Therapeutics plans to commence enrollment at the BDTX-1535 200 mg daily dose in two expansion cohorts of NSCLC patients who had received up to two prior lines of therapy, including a third-generation EGFR TKI.

Upcoming Milestones for BDTX-1535

Black Diamond Therapeutics has outlined several significant milestones for BDTX-1535. These include the initiation of dose expansion cohorts in H2 2023, presentation of the full BDTX-1535 dose escalation data at a medical conference in Q4 2023, and a meeting with the FDA to discuss potential accelerated approval pathways for NSCLC in the same quarter. Furthermore, an update on the BDTX-1535 Phase 1 dose escalation data for recurrent GBM patients is expected in Q4 2023.

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

The post Black Diamond Therapeutics’ (NASDAQ: BDTX) BDTX-1535 Proves Promising for EGFR Mutated NSCLC and GBM appeared first on Spotlight Growth.

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