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For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

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Mighty Mitochondria: This Company is Developing A Novel Drug for Kidney Disease By Targeting The Powerhouse Of Human Cells

You may remember learning that mitochondria are the powerhouse of the cells, but do you know the dangers that result if these cell superheroes get sick?

In addition to powering healthy cells, mitochondria are also important players in certain diseases. This is especially true in kidney disease. While kidney cells make up only 1% of our body weight, they consume over 10% of our daily energy supply. When either acute or chronic disease strikes these vital organs, the health of the mitochondria can literally be the difference between life and death. Specialized pores inside the mitochondria called mitochondrial permeability transition (MPT) pores regulate programmed cell death—or apoptosis. Under disease conditions, MPT pores are stuck open allowing fluid to rush in causing swelling which leads to the death of the cell.

What if you could close these pores? Would that restore the normal function of damaged mitochondria and possibly be a cure for disease? That’s just what a California-based biotechnology company specializing in diseases of the kidney is hoping to do.

Unicycive Therapeutics Inc. (NASDAQ: UNCY) recently announced findings from a preclinical trial for their drug called UNI-494 that reduced a known biomarker of ischemic injury that is present in acute kidney injury (AKI), a result described as “very encouraging” by a leading expert in the field of AKI research. UNI-494 is a potent activator of the mitochondrial adenosine triphosphate-sensitive (ATP) potassium channel (mitoKATP). That’s important because when these channels are activated, they close the MPT pores and prevent the damage that leads to cell death.

Mitochondrial dysfunction is closely associated with kidney issues, including (AKI). Affecting over 13 million people worldwide each year, AKI increases the risk of mortality by 23.9% in adults and 13.8% in children. Companies like DaVita Inc. (NYSE: DVA) and Akebia Therapeutics Inc. (NASDAQ: AKBA) are among the companies seeking solutions to a variety of renal diseases. Unbelievably, however, there are still no Food and Drug Administration (FDA)-approved drugs for AKI.

Sadly, damage to mitochondria is seen in other diseases as well, including cardiovascular, liver and eye degeneration. While Unicycive is initially focused on producing a treatment for AKI and chronic kidney disease (CKD), it believes that the mechanism of action of UNI-494 may also be applicable for the treatment of other diseases where the mitochondria are affected.

The company is now beginning its next milestone, filing to begin Phase 1 human trials of the drug.

“We are excited to report this key finding,” Unicycive CEO Dr. Shalabh Gupta said. “We remain on track to file a regulatory submission by the end of 2022 that will allow us to initiate our Phase 1 study with UNI-494.”

If the FDA approves the drug, it would be the first drug for AKI available on the market.

Unicycive Therapeutics is a biotechnology company developing novel treatments for kidney diseases. Unicycive’s lead drug, Renazorb, is a novel phosphate binding agent being developed for the treatment of hyperphosphatemia. UNI-494 is a patent-protected new chemical entity in late preclinical development for the treatment of acute kidney injury.

This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice.

Contact Details

Anne Marie Fields - Stern Investor Relations

+1 212-362-1200

annemarie.fields@sternir.com

Company Website

https://unicycive.com/

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