Recent Quotes View Full List My Watchlist Create Watchlist Indicators DJI Nasdaq Composite SPX Gold Crude Oil Hydroworld Market Index Markets Stocks ETFs Tools Overview News Currencies International Treasuries NuCana Reports First Quarter 2024 Financial Results and Provides Business Update By: NuCana plc via GlobeNewswire May 16, 2024 at 16:01 PM EDT Key Data Readouts on Track for All Programs in 2024 Randomized Phase 2 Study of 182 Second-Line Colorectal Cancer Patients Fully Enrolled NUC-7738 plus Pembrolizumab Demonstrated Encouraging Anti-Cancer Activity in Several Patients who were Resistant to PD-1 Inhibitors Anticipated Cash Runway into Q1 2025 EDINBURGH, United Kingdom, May 16, 2024 (GLOBE NEWSWIRE) -- NuCana plc (NASDAQ: NCNA) announced financial results for the first quarter ended March 31, 2024 and provided an update on its broad clinical development program with its transformative ProTide therapeutics. As of March 31, 2024, NuCana had cash and cash equivalents of £12.9 million compared to £17.2 million at December 31, 2023. NuCana continues to advance its numerous clinical programs and reported a net loss of £6.8 million for the quarter ended March 31, 2024, as compared to a net loss of £7.9 million for the quarter ended March 31, 2023. Basic and diluted loss per share was £0.13 for the quarter ended March 31, 2024, as compared to £0.15 per share for the comparable quarter ended March 31, 2023. “Our focus remains on advancing our innovative ProTide pipeline to develop more efficacious and safer medicines for patients with cancer,” said Hugh S. Griffith, NuCana’s Founder and Chief Executive Officer. “NUC-3373, a transformation of 5-FU, is currently being investigated in three ongoing clinical studies. Our randomized Phase 2 study (NuTide:323) is now fully enrolled with 182 patients, and compares NUC-3373 in combination with irinotecan, leucovorin and bevacizumab (NUFIRI + bev) with the standard of care, 5-FU in combination with irinotecan, leucovorin and bevacizumab (FOLFIRI + bev) for the second-line treatment of patients with metastatic colorectal cancer. We look forward to announcing initial data from this study in 2024. We also plan to announce additional data from our ongoing Phase 1/2 study (NuTide:302) of NUFIRI + bev and NUFOX + bev in patients with metastatic colorectal cancer this year. Our Phase 1b/2 study (NuTide:303) of NUC-3373 in combination with pembrolizumab in patients with solid tumors and in combination with docetaxel in patients with lung cancer also remains on track with data readouts expected in 2024.” Mr. Griffith continued: “Moving to NUC-7738, we recently presented exciting data at the American Association of Cancer Research (AACR) Annual Meeting. These data highlighted NUC-7738’s ability to disrupt RNA polyadenylation, leading to profound alterations in the tumor biology of the patients’ cancers. We believe that this finding provides a rationale as to why NUC-7738 plus pembrolizumab has achieved encouraging anti-cancer activity in several patients who were resistant to PD-1 inhibitors. We are evaluating NUC-7738 in an ongoing Phase 1/2 study (NuTide:701) as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in PD-1 inhibitor-resistant patients with melanoma. We plan to announce additional data from this study in 2024.” Mr. Griffith concluded, “We look forward to providing updates from all of our ongoing clinical studies this year as we continue working towards our mission of improving treatment outcomes for patients with cancer.” 2024 Anticipated Milestones NUC-3373 (a ProTide transformation of 5-FU)In 2024, NuCana expects to: Announce data from the randomized Phase 2 (NuTide:323) study of NUFIRI + bev compared to the standard of care FOLFIRI + bev for the second-line treatment of patients with metastatic colorectal cancer;Announce data from the Phase 1b/2 (NuTide:302) study of NUFIRI + bev and NUFOX + bev for the second-line treatment of patients with metastatic colorectal cancer; andAnnounce data from the Phase 1b/2 (NuTide:303) modular study of NUC-3373 in combination with pembrolizumab in patients with solid tumors and in combination with docetaxel in patients with lung cancer. NUC-7738 (a ProTide transformation of 3’-deoxyadenosine)In 2024, NuCana expects to: Announce data from the Phase 2 part of the Phase 1/2 study (NuTide:701) of NUC-7738 in combination with pembrolizumab in patients with melanoma. About NuCana NuCana is a clinical-stage biopharmaceutical company focused on significantly improving treatment outcomes for patients with cancer by applying our ProTide technology to transform some of the most widely prescribed chemotherapy agents, nucleoside analogs, into more effective and safer medicines. While these conventional agents remain part of the standard of care for the treatment of many solid and hematological tumors, they have significant shortcomings that limit their efficacy and they are often poorly tolerated. Utilizing our proprietary technology, we are developing new medicines, ProTides, designed to overcome the key limitations of nucleoside analogs and generate much higher concentrations of anti-cancer metabolites in cancer cells. NuCana’s pipeline includes NUC-3373 and NUC-7738. NUC-3373 is a new chemical entity derived from the nucleoside analog 5-fluorouracil, a widely used chemotherapy agent. NUC-3373 is currently being evaluated in three ongoing clinical studies: a Phase 1b/2 study (NuTide:302) in combination with leucovorin, irinotecan or oxaliplatin, and bevacizumab in patients with metastatic colorectal cancer; a randomized Phase 2 study (NuTide:323) in combination with leucovorin, irinotecan, and bevacizumab for the second-line treatment of patients with metastatic colorectal cancer; and a Phase 1b/2 modular study (NuTide:303) of NUC-3373 in combination with the PD-1 inhibitor pembrolizumab for patients with advanced solid tumors and in combination with docetaxel for patients with lung cancer. NUC-7738 is a transformation of 3’-deoxyadenosine, a novel anti-cancer nucleoside analog. NUC-7738 is in the Phase 2 part of a Phase 1/2 study which is evaluating NUC-7738 as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in patients with melanoma. Forward-Looking Statements This press release may contain “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information currently available to management of NuCana plc (the “Company”). All statements other than statements of historical fact contained in this press release are forward-looking statements, including statements concerning the Company’s planned and ongoing clinical studies for the Company’s product candidates and the potential advantages of those product candidates, including NUC-3373 and NUC-7738; the initiation, enrollment, timing, progress, release of data from and results of those planned and ongoing clinical studies; the Company’s goals with respect to the development, regulatory pathway and potential use, if approved, of each of its product candidates; the utility of prior non-clinical and clinical data in determining future clinical results; and the sufficiency of the Company’s current cash, cash equivalents and marketable securities to fund its planned operations into Q1 2025. In some cases, you can identify forward-looking statements by terminology such as “may,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “potential” or “continue” or the negative of these terms or other comparable terminology. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the Company’s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks and uncertainties include, but are not limited to, the timing of receipt of our U.K. research and development tax credit cash rebates expected to be received in 2024 and the other risks and uncertainties set forth in the “Risk Factors” section of the Company’s Annual Report on Form 20-F for the year ended December 31, 2023 filed with the Securities and Exchange Commission (“SEC”) on March 20, 2024, and subsequent reports that the Company files with the SEC. Forward-looking statements represent the Company’s beliefs and assumptions only as of the date of this press release. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee future results, levels of activity, performance or achievements. Except as required by law, the Company assumes no obligation to publicly update any forward-looking statements for any reason after the date of this press release to conform any of the forward-looking statements to actual results or to changes in its expectations. Unaudited Condensed Consolidated Statements of Operations For the Three Months EndedMarch 31, 2024 2023 (in thousands, except per share data) ££Research and development expenses (6,783) (6,805) Administrative expenses (1,581) (1,648) Net foreign exchange gains (losses) 95 (695) Operating loss (8,269) (9,148) Finance income 126 287 Loss before tax (8,143) (8,861) Income tax credit 1,305 994 Loss for the period (6,838) (7,867) Basic and diluted loss per share (0.13) (0.15) Unaudited Condensed Consolidated Statements of Financial Position As At March 31,2024 December 31, 2023 (in thousands) ££Assets Non-current assets Intangible assets 2,165 2,128 Property, plant and equipment 430 521 Deferred tax asset 156 143 2,751 2,792 Current assets Prepayments, accrued income and other receivables 2,766 2,671 Current income tax receivable 6,416 5,123 Cash and cash equivalents 12,868 17,225 22,050 25,019 Total assets 24,801 27,811 Equity and liabilities Capital and reserves Share capital and share premium 144,870 143,420 Other reserves 79,633 79,173 Accumulated deficit (214,374) (207,706) Total equity attributable to equity holders of the Company 10,129 14,887 Non-current liabilities Provisions 58 58 Lease liabilities 172 190 230 248 Current liabilities Trade payables 5,764 3,375 Payroll taxes and social security 214 155 Accrued expenditure 8,297 8,940 Lease liabilities 167 206 14,442 12,676 Total liabilities 14,672 12,924 Total equity and liabilities 24,801 27,811 Unaudited Condensed Consolidated Statements of Cash Flows For the Three Months EndedMarch 31, 2024 2023 (in thousands) ££Cash flows from operating activities Loss for the period(6,838) (7,867) Adjustments for: Income tax credit(1,305) (994) Amortization and depreciation136 143 Movement in provisions- (55) Finance income(126) (287) Interest expense on lease liabilities5 8 Share-based payments626 1,141 Net foreign exchange (gains) losses(98) 726 (7,600) (7,185) Movements in working capital: Increase in prepayments, accrued income and other receivables(87) (463) Increase in trade payables2,390 888 Decrease in payroll taxes, social security and accrued expenditure(586) (3,575) Movements in working capital1,717 (3,150) Cash used in operations(5,883) (10,335) Net income tax received- - Net cash used in operating activities(5,883) (10,335) Cash flows from investing activities Interest received124 322 Payments for intangible assets(81) (159) Net cash from investing activities43 163 Cash flows from financing activities Payments for lease liabilities(64) (42) Proceeds from issue of share capital – exercise of share options3 1 Proceeds from issue of share capital1,492 - Share issue expenses(45) - Net cash from (used in) financing activities1,386 (41) Net decrease in cash and cash equivalents(4,454) (10,213) Cash and cash equivalents at beginning of period17,225 41,912 Effect of exchange rate changes on cash and cash equivalents97 (698) Cash and cash equivalents at end of period12,868 31,001 For more information, please contact: NuCana plcHugh S. GriffithChief Executive Officer +44 131-357-1111 info@nucana.com ICR WestwickeChris Brinzey+1 339-970-2843chris.brinzey@westwicke.com Data & News supplied by www.cloudquote.io Stock quotes supplied by Barchart Quotes delayed at least 20 minutes. By accessing this page, you agree to the following Privacy Policy and Terms and Conditions.
NuCana Reports First Quarter 2024 Financial Results and Provides Business Update By: NuCana plc via GlobeNewswire May 16, 2024 at 16:01 PM EDT Key Data Readouts on Track for All Programs in 2024 Randomized Phase 2 Study of 182 Second-Line Colorectal Cancer Patients Fully Enrolled NUC-7738 plus Pembrolizumab Demonstrated Encouraging Anti-Cancer Activity in Several Patients who were Resistant to PD-1 Inhibitors Anticipated Cash Runway into Q1 2025 EDINBURGH, United Kingdom, May 16, 2024 (GLOBE NEWSWIRE) -- NuCana plc (NASDAQ: NCNA) announced financial results for the first quarter ended March 31, 2024 and provided an update on its broad clinical development program with its transformative ProTide therapeutics. As of March 31, 2024, NuCana had cash and cash equivalents of £12.9 million compared to £17.2 million at December 31, 2023. NuCana continues to advance its numerous clinical programs and reported a net loss of £6.8 million for the quarter ended March 31, 2024, as compared to a net loss of £7.9 million for the quarter ended March 31, 2023. Basic and diluted loss per share was £0.13 for the quarter ended March 31, 2024, as compared to £0.15 per share for the comparable quarter ended March 31, 2023. “Our focus remains on advancing our innovative ProTide pipeline to develop more efficacious and safer medicines for patients with cancer,” said Hugh S. Griffith, NuCana’s Founder and Chief Executive Officer. “NUC-3373, a transformation of 5-FU, is currently being investigated in three ongoing clinical studies. Our randomized Phase 2 study (NuTide:323) is now fully enrolled with 182 patients, and compares NUC-3373 in combination with irinotecan, leucovorin and bevacizumab (NUFIRI + bev) with the standard of care, 5-FU in combination with irinotecan, leucovorin and bevacizumab (FOLFIRI + bev) for the second-line treatment of patients with metastatic colorectal cancer. We look forward to announcing initial data from this study in 2024. We also plan to announce additional data from our ongoing Phase 1/2 study (NuTide:302) of NUFIRI + bev and NUFOX + bev in patients with metastatic colorectal cancer this year. Our Phase 1b/2 study (NuTide:303) of NUC-3373 in combination with pembrolizumab in patients with solid tumors and in combination with docetaxel in patients with lung cancer also remains on track with data readouts expected in 2024.” Mr. Griffith continued: “Moving to NUC-7738, we recently presented exciting data at the American Association of Cancer Research (AACR) Annual Meeting. These data highlighted NUC-7738’s ability to disrupt RNA polyadenylation, leading to profound alterations in the tumor biology of the patients’ cancers. We believe that this finding provides a rationale as to why NUC-7738 plus pembrolizumab has achieved encouraging anti-cancer activity in several patients who were resistant to PD-1 inhibitors. We are evaluating NUC-7738 in an ongoing Phase 1/2 study (NuTide:701) as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in PD-1 inhibitor-resistant patients with melanoma. We plan to announce additional data from this study in 2024.” Mr. Griffith concluded, “We look forward to providing updates from all of our ongoing clinical studies this year as we continue working towards our mission of improving treatment outcomes for patients with cancer.” 2024 Anticipated Milestones NUC-3373 (a ProTide transformation of 5-FU)In 2024, NuCana expects to: Announce data from the randomized Phase 2 (NuTide:323) study of NUFIRI + bev compared to the standard of care FOLFIRI + bev for the second-line treatment of patients with metastatic colorectal cancer;Announce data from the Phase 1b/2 (NuTide:302) study of NUFIRI + bev and NUFOX + bev for the second-line treatment of patients with metastatic colorectal cancer; andAnnounce data from the Phase 1b/2 (NuTide:303) modular study of NUC-3373 in combination with pembrolizumab in patients with solid tumors and in combination with docetaxel in patients with lung cancer. NUC-7738 (a ProTide transformation of 3’-deoxyadenosine)In 2024, NuCana expects to: Announce data from the Phase 2 part of the Phase 1/2 study (NuTide:701) of NUC-7738 in combination with pembrolizumab in patients with melanoma. About NuCana NuCana is a clinical-stage biopharmaceutical company focused on significantly improving treatment outcomes for patients with cancer by applying our ProTide technology to transform some of the most widely prescribed chemotherapy agents, nucleoside analogs, into more effective and safer medicines. While these conventional agents remain part of the standard of care for the treatment of many solid and hematological tumors, they have significant shortcomings that limit their efficacy and they are often poorly tolerated. Utilizing our proprietary technology, we are developing new medicines, ProTides, designed to overcome the key limitations of nucleoside analogs and generate much higher concentrations of anti-cancer metabolites in cancer cells. NuCana’s pipeline includes NUC-3373 and NUC-7738. NUC-3373 is a new chemical entity derived from the nucleoside analog 5-fluorouracil, a widely used chemotherapy agent. NUC-3373 is currently being evaluated in three ongoing clinical studies: a Phase 1b/2 study (NuTide:302) in combination with leucovorin, irinotecan or oxaliplatin, and bevacizumab in patients with metastatic colorectal cancer; a randomized Phase 2 study (NuTide:323) in combination with leucovorin, irinotecan, and bevacizumab for the second-line treatment of patients with metastatic colorectal cancer; and a Phase 1b/2 modular study (NuTide:303) of NUC-3373 in combination with the PD-1 inhibitor pembrolizumab for patients with advanced solid tumors and in combination with docetaxel for patients with lung cancer. NUC-7738 is a transformation of 3’-deoxyadenosine, a novel anti-cancer nucleoside analog. NUC-7738 is in the Phase 2 part of a Phase 1/2 study which is evaluating NUC-7738 as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in patients with melanoma. Forward-Looking Statements This press release may contain “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information currently available to management of NuCana plc (the “Company”). All statements other than statements of historical fact contained in this press release are forward-looking statements, including statements concerning the Company’s planned and ongoing clinical studies for the Company’s product candidates and the potential advantages of those product candidates, including NUC-3373 and NUC-7738; the initiation, enrollment, timing, progress, release of data from and results of those planned and ongoing clinical studies; the Company’s goals with respect to the development, regulatory pathway and potential use, if approved, of each of its product candidates; the utility of prior non-clinical and clinical data in determining future clinical results; and the sufficiency of the Company’s current cash, cash equivalents and marketable securities to fund its planned operations into Q1 2025. In some cases, you can identify forward-looking statements by terminology such as “may,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “potential” or “continue” or the negative of these terms or other comparable terminology. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the Company’s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks and uncertainties include, but are not limited to, the timing of receipt of our U.K. research and development tax credit cash rebates expected to be received in 2024 and the other risks and uncertainties set forth in the “Risk Factors” section of the Company’s Annual Report on Form 20-F for the year ended December 31, 2023 filed with the Securities and Exchange Commission (“SEC”) on March 20, 2024, and subsequent reports that the Company files with the SEC. Forward-looking statements represent the Company’s beliefs and assumptions only as of the date of this press release. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee future results, levels of activity, performance or achievements. Except as required by law, the Company assumes no obligation to publicly update any forward-looking statements for any reason after the date of this press release to conform any of the forward-looking statements to actual results or to changes in its expectations. Unaudited Condensed Consolidated Statements of Operations For the Three Months EndedMarch 31, 2024 2023 (in thousands, except per share data) ££Research and development expenses (6,783) (6,805) Administrative expenses (1,581) (1,648) Net foreign exchange gains (losses) 95 (695) Operating loss (8,269) (9,148) Finance income 126 287 Loss before tax (8,143) (8,861) Income tax credit 1,305 994 Loss for the period (6,838) (7,867) Basic and diluted loss per share (0.13) (0.15) Unaudited Condensed Consolidated Statements of Financial Position As At March 31,2024 December 31, 2023 (in thousands) ££Assets Non-current assets Intangible assets 2,165 2,128 Property, plant and equipment 430 521 Deferred tax asset 156 143 2,751 2,792 Current assets Prepayments, accrued income and other receivables 2,766 2,671 Current income tax receivable 6,416 5,123 Cash and cash equivalents 12,868 17,225 22,050 25,019 Total assets 24,801 27,811 Equity and liabilities Capital and reserves Share capital and share premium 144,870 143,420 Other reserves 79,633 79,173 Accumulated deficit (214,374) (207,706) Total equity attributable to equity holders of the Company 10,129 14,887 Non-current liabilities Provisions 58 58 Lease liabilities 172 190 230 248 Current liabilities Trade payables 5,764 3,375 Payroll taxes and social security 214 155 Accrued expenditure 8,297 8,940 Lease liabilities 167 206 14,442 12,676 Total liabilities 14,672 12,924 Total equity and liabilities 24,801 27,811 Unaudited Condensed Consolidated Statements of Cash Flows For the Three Months EndedMarch 31, 2024 2023 (in thousands) ££Cash flows from operating activities Loss for the period(6,838) (7,867) Adjustments for: Income tax credit(1,305) (994) Amortization and depreciation136 143 Movement in provisions- (55) Finance income(126) (287) Interest expense on lease liabilities5 8 Share-based payments626 1,141 Net foreign exchange (gains) losses(98) 726 (7,600) (7,185) Movements in working capital: Increase in prepayments, accrued income and other receivables(87) (463) Increase in trade payables2,390 888 Decrease in payroll taxes, social security and accrued expenditure(586) (3,575) Movements in working capital1,717 (3,150) Cash used in operations(5,883) (10,335) Net income tax received- - Net cash used in operating activities(5,883) (10,335) Cash flows from investing activities Interest received124 322 Payments for intangible assets(81) (159) Net cash from investing activities43 163 Cash flows from financing activities Payments for lease liabilities(64) (42) Proceeds from issue of share capital – exercise of share options3 1 Proceeds from issue of share capital1,492 - Share issue expenses(45) - Net cash from (used in) financing activities1,386 (41) Net decrease in cash and cash equivalents(4,454) (10,213) Cash and cash equivalents at beginning of period17,225 41,912 Effect of exchange rate changes on cash and cash equivalents97 (698) Cash and cash equivalents at end of period12,868 31,001 For more information, please contact: NuCana plcHugh S. GriffithChief Executive Officer +44 131-357-1111 info@nucana.com ICR WestwickeChris Brinzey+1 339-970-2843chris.brinzey@westwicke.com
Key Data Readouts on Track for All Programs in 2024 Randomized Phase 2 Study of 182 Second-Line Colorectal Cancer Patients Fully Enrolled NUC-7738 plus Pembrolizumab Demonstrated Encouraging Anti-Cancer Activity in Several Patients who were Resistant to PD-1 Inhibitors Anticipated Cash Runway into Q1 2025 EDINBURGH, United Kingdom, May 16, 2024 (GLOBE NEWSWIRE) -- NuCana plc (NASDAQ: NCNA) announced financial results for the first quarter ended March 31, 2024 and provided an update on its broad clinical development program with its transformative ProTide therapeutics. As of March 31, 2024, NuCana had cash and cash equivalents of £12.9 million compared to £17.2 million at December 31, 2023. NuCana continues to advance its numerous clinical programs and reported a net loss of £6.8 million for the quarter ended March 31, 2024, as compared to a net loss of £7.9 million for the quarter ended March 31, 2023. Basic and diluted loss per share was £0.13 for the quarter ended March 31, 2024, as compared to £0.15 per share for the comparable quarter ended March 31, 2023. “Our focus remains on advancing our innovative ProTide pipeline to develop more efficacious and safer medicines for patients with cancer,” said Hugh S. Griffith, NuCana’s Founder and Chief Executive Officer. “NUC-3373, a transformation of 5-FU, is currently being investigated in three ongoing clinical studies. Our randomized Phase 2 study (NuTide:323) is now fully enrolled with 182 patients, and compares NUC-3373 in combination with irinotecan, leucovorin and bevacizumab (NUFIRI + bev) with the standard of care, 5-FU in combination with irinotecan, leucovorin and bevacizumab (FOLFIRI + bev) for the second-line treatment of patients with metastatic colorectal cancer. We look forward to announcing initial data from this study in 2024. We also plan to announce additional data from our ongoing Phase 1/2 study (NuTide:302) of NUFIRI + bev and NUFOX + bev in patients with metastatic colorectal cancer this year. Our Phase 1b/2 study (NuTide:303) of NUC-3373 in combination with pembrolizumab in patients with solid tumors and in combination with docetaxel in patients with lung cancer also remains on track with data readouts expected in 2024.” Mr. Griffith continued: “Moving to NUC-7738, we recently presented exciting data at the American Association of Cancer Research (AACR) Annual Meeting. These data highlighted NUC-7738’s ability to disrupt RNA polyadenylation, leading to profound alterations in the tumor biology of the patients’ cancers. We believe that this finding provides a rationale as to why NUC-7738 plus pembrolizumab has achieved encouraging anti-cancer activity in several patients who were resistant to PD-1 inhibitors. We are evaluating NUC-7738 in an ongoing Phase 1/2 study (NuTide:701) as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in PD-1 inhibitor-resistant patients with melanoma. We plan to announce additional data from this study in 2024.” Mr. Griffith concluded, “We look forward to providing updates from all of our ongoing clinical studies this year as we continue working towards our mission of improving treatment outcomes for patients with cancer.” 2024 Anticipated Milestones NUC-3373 (a ProTide transformation of 5-FU)In 2024, NuCana expects to: Announce data from the randomized Phase 2 (NuTide:323) study of NUFIRI + bev compared to the standard of care FOLFIRI + bev for the second-line treatment of patients with metastatic colorectal cancer;Announce data from the Phase 1b/2 (NuTide:302) study of NUFIRI + bev and NUFOX + bev for the second-line treatment of patients with metastatic colorectal cancer; andAnnounce data from the Phase 1b/2 (NuTide:303) modular study of NUC-3373 in combination with pembrolizumab in patients with solid tumors and in combination with docetaxel in patients with lung cancer. NUC-7738 (a ProTide transformation of 3’-deoxyadenosine)In 2024, NuCana expects to: Announce data from the Phase 2 part of the Phase 1/2 study (NuTide:701) of NUC-7738 in combination with pembrolizumab in patients with melanoma. About NuCana NuCana is a clinical-stage biopharmaceutical company focused on significantly improving treatment outcomes for patients with cancer by applying our ProTide technology to transform some of the most widely prescribed chemotherapy agents, nucleoside analogs, into more effective and safer medicines. While these conventional agents remain part of the standard of care for the treatment of many solid and hematological tumors, they have significant shortcomings that limit their efficacy and they are often poorly tolerated. Utilizing our proprietary technology, we are developing new medicines, ProTides, designed to overcome the key limitations of nucleoside analogs and generate much higher concentrations of anti-cancer metabolites in cancer cells. NuCana’s pipeline includes NUC-3373 and NUC-7738. NUC-3373 is a new chemical entity derived from the nucleoside analog 5-fluorouracil, a widely used chemotherapy agent. NUC-3373 is currently being evaluated in three ongoing clinical studies: a Phase 1b/2 study (NuTide:302) in combination with leucovorin, irinotecan or oxaliplatin, and bevacizumab in patients with metastatic colorectal cancer; a randomized Phase 2 study (NuTide:323) in combination with leucovorin, irinotecan, and bevacizumab for the second-line treatment of patients with metastatic colorectal cancer; and a Phase 1b/2 modular study (NuTide:303) of NUC-3373 in combination with the PD-1 inhibitor pembrolizumab for patients with advanced solid tumors and in combination with docetaxel for patients with lung cancer. NUC-7738 is a transformation of 3’-deoxyadenosine, a novel anti-cancer nucleoside analog. NUC-7738 is in the Phase 2 part of a Phase 1/2 study which is evaluating NUC-7738 as a monotherapy in patients with advanced solid tumors and in combination with pembrolizumab in patients with melanoma. Forward-Looking Statements This press release may contain “forward-looking” statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are based on the beliefs and assumptions and on information currently available to management of NuCana plc (the “Company”). All statements other than statements of historical fact contained in this press release are forward-looking statements, including statements concerning the Company’s planned and ongoing clinical studies for the Company’s product candidates and the potential advantages of those product candidates, including NUC-3373 and NUC-7738; the initiation, enrollment, timing, progress, release of data from and results of those planned and ongoing clinical studies; the Company’s goals with respect to the development, regulatory pathway and potential use, if approved, of each of its product candidates; the utility of prior non-clinical and clinical data in determining future clinical results; and the sufficiency of the Company’s current cash, cash equivalents and marketable securities to fund its planned operations into Q1 2025. In some cases, you can identify forward-looking statements by terminology such as “may,” “will,” “should,” “expects,” “plans,” “anticipates,” “believes,” “estimates,” “predicts,” “potential” or “continue” or the negative of these terms or other comparable terminology. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause the Company’s actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements. These risks and uncertainties include, but are not limited to, the timing of receipt of our U.K. research and development tax credit cash rebates expected to be received in 2024 and the other risks and uncertainties set forth in the “Risk Factors” section of the Company’s Annual Report on Form 20-F for the year ended December 31, 2023 filed with the Securities and Exchange Commission (“SEC”) on March 20, 2024, and subsequent reports that the Company files with the SEC. Forward-looking statements represent the Company’s beliefs and assumptions only as of the date of this press release. Although the Company believes that the expectations reflected in the forward-looking statements are reasonable, it cannot guarantee future results, levels of activity, performance or achievements. Except as required by law, the Company assumes no obligation to publicly update any forward-looking statements for any reason after the date of this press release to conform any of the forward-looking statements to actual results or to changes in its expectations. Unaudited Condensed Consolidated Statements of Operations For the Three Months EndedMarch 31, 2024 2023 (in thousands, except per share data) ££Research and development expenses (6,783) (6,805) Administrative expenses (1,581) (1,648) Net foreign exchange gains (losses) 95 (695) Operating loss (8,269) (9,148) Finance income 126 287 Loss before tax (8,143) (8,861) Income tax credit 1,305 994 Loss for the period (6,838) (7,867) Basic and diluted loss per share (0.13) (0.15) Unaudited Condensed Consolidated Statements of Financial Position As At March 31,2024 December 31, 2023 (in thousands) ££Assets Non-current assets Intangible assets 2,165 2,128 Property, plant and equipment 430 521 Deferred tax asset 156 143 2,751 2,792 Current assets Prepayments, accrued income and other receivables 2,766 2,671 Current income tax receivable 6,416 5,123 Cash and cash equivalents 12,868 17,225 22,050 25,019 Total assets 24,801 27,811 Equity and liabilities Capital and reserves Share capital and share premium 144,870 143,420 Other reserves 79,633 79,173 Accumulated deficit (214,374) (207,706) Total equity attributable to equity holders of the Company 10,129 14,887 Non-current liabilities Provisions 58 58 Lease liabilities 172 190 230 248 Current liabilities Trade payables 5,764 3,375 Payroll taxes and social security 214 155 Accrued expenditure 8,297 8,940 Lease liabilities 167 206 14,442 12,676 Total liabilities 14,672 12,924 Total equity and liabilities 24,801 27,811 Unaudited Condensed Consolidated Statements of Cash Flows For the Three Months EndedMarch 31, 2024 2023 (in thousands) ££Cash flows from operating activities Loss for the period(6,838) (7,867) Adjustments for: Income tax credit(1,305) (994) Amortization and depreciation136 143 Movement in provisions- (55) Finance income(126) (287) Interest expense on lease liabilities5 8 Share-based payments626 1,141 Net foreign exchange (gains) losses(98) 726 (7,600) (7,185) Movements in working capital: Increase in prepayments, accrued income and other receivables(87) (463) Increase in trade payables2,390 888 Decrease in payroll taxes, social security and accrued expenditure(586) (3,575) Movements in working capital1,717 (3,150) Cash used in operations(5,883) (10,335) Net income tax received- - Net cash used in operating activities(5,883) (10,335) Cash flows from investing activities Interest received124 322 Payments for intangible assets(81) (159) Net cash from investing activities43 163 Cash flows from financing activities Payments for lease liabilities(64) (42) Proceeds from issue of share capital – exercise of share options3 1 Proceeds from issue of share capital1,492 - Share issue expenses(45) - Net cash from (used in) financing activities1,386 (41) Net decrease in cash and cash equivalents(4,454) (10,213) Cash and cash equivalents at beginning of period17,225 41,912 Effect of exchange rate changes on cash and cash equivalents97 (698) Cash and cash equivalents at end of period12,868 31,001 For more information, please contact: NuCana plcHugh S. GriffithChief Executive Officer +44 131-357-1111 info@nucana.com ICR WestwickeChris Brinzey+1 339-970-2843chris.brinzey@westwicke.com