Monrovia, California Dec 7, 2022 (Issuewire.com) - Results of an Oak Crest Institute of Science ongoing clinical study of workplace acquired SARS-CoV-2 infections show the importance of continuous sampling protocols for understanding virus kinetics in humans with COVID 19.

The results, published in the Dec 2022 issue of Microbiology Spectrum, followed two vaccinated participants, a male and a female, from the initial time of COVID-19 infection until the virus was cleared from the body. The findings showed SARS-CoV-2 doubling times to be similar for vaccinated and unvaccinated subjects, but vaccinated individuals can clear the virus from the body faster than those who are unvaccinated.

According to Manjula Gunawardana, M.P.H, the lead author, "doubling times of the SARS-CoV-2 virus were similar for vaccinated and unvaccinated individuals, but vaccinated individuals had a shorter clearance phase than unvaccinated subjects. This suggests that while vaccination does not always prevent infection, it can improve recovery times."

"Our continuous testing protocols," said Marc Baum, PhD the senior author, "beginning before participants were infected, means we can track each infection from its very beginning to conclusion. This continuous surveillance helped us detect a virus mutation occurring in one of the participants during the time they tested positive."

Here is a link to the full report: Gunawardana et al. Clinical SARS-CoV-2 Kinetic Profiles Are Dependent on the Viral Strain and Host Vaccination Status. Microbiol Spectr. 2022 Dec 1:e0446922. doi: 10.1128/spectrum.04469-22. Epub ahead of print. PMID: 36453916.

https://pubmed.ncbi.nlm.nih.gov/36453916/

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