The following is a detailed breakdown:

Effects of Diosmin on the Brain

Antioxidant and Neuroprotective Effects

Diosmin has potent antioxidant properties, neutralizing free radicals and reducing oxidative stress-induced damage to nerve cells. Oxidative stress is a key pathological mechanism in many neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. By reducing oxidative stress, diosmin may help slow the progression of these diseases.

For example, in rodent models, diosmin attenuated neuronal damage under conditions of cerebral ischemia (restricted cerebral blood flow). This suggests potential benefits in preventing stroke-related injuries.

Improving Cerebral Blood Flow: Diosmin improves microcirculation and venous tone. Diosmin strengthens venous tone, improves microcirculation, and promotes blood and lymphatic return. Good microcirculation is crucial for maintaining healthy nerve cells, which are highly sensitive to ischemia and hypoxia. By improving microcirculation, diosmin may help reduce nerve damage caused by ischemia and hypoxia.

Promoting Neural Repair: Some studies suggest that diosmin may accelerate the repair and regeneration of damaged nerves by promoting the expression of nerve growth factor. Nerve growth factor plays a key role in neural development and regeneration, so this effect of diosmin may help restore neurological function.

Improving Cerebral Blood Flow and Microcirculation: Although its primary effects are on the venous system, diosmin also has positive effects on microcirculation, including capillaries. Good cerebral blood perfusion is crucial for delivering oxygen and nutrients and removing metabolic waste. Diosmin works by increasing vascular tone and reducing blood stasis. Diosmin may indirectly improve brain microcirculation, providing better support for brain cells. Diosmin has been shown to strengthen the integrity of blood vessel walls and reduce vascular permeability. In the brain, this means it may help stabilize and repair a damaged blood-brain barrier, preventing further deterioration.

Potential Role in Anxiety and Depression

Preliminary animal studies suggest that diosmin may have anxiolytic and antidepressant-like effects.

These effects are thought to be related to its antioxidant properties and possible effects on neurotransmitter balance.

Cognitive Support

While human data remain limited, diosmin's vasoprotective, antioxidant, and anti-inflammatory properties may indirectly support: Memory retention；concentration and attention; brain energy metabolism.

Currently, the majority of evidence supporting diosmin's beneficial effects on the brain comes from animal studies and cell-based studies. Although diosmin's primary use is in the treatment of venous and lymphatic insufficiency, its potential neuroprotective effects offer new possibilities for its use in neurodegenerative diseases. Although the results are encouraging, there is still a long way to go from "laboratory potential" to "clinically effective drugs" in research on the effects of diosmin on the human brain.

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