Launch offers premium products to customers and patients who seek advanced options in medical aesthetics

Merz Aesthetics, the world’s largest dedicated medical aesthetics business, has launched flagship products XEOMIN^® (incobotulinumtoxinA) and RADIESSE^® in China. With this expansion into the world’s fastest-growing market, Merz Aesthetics continues to extend the reach of its comprehensive injectables portfolio.

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Merz Aesthetics Team Onsite at Launch

“China is a key strategic market for our global business, and this milestone reflects our incredible momentum as a category leader,” said Bob Rhatigan, CEO, Merz Aesthetics. “Since becoming a standalone business in 2020, we have consistently outpaced the growth in our industry, and we remain committed to increasing access to our premium products across the world.”

The launch gives patients in China access to the high standards for innovation, quality, safety and patient-centric benefits that XEOMIN and RADIESSE offer.

• XEOMIN is the first and only double-purified toxin that uses XTRACT Technology™ to eliminate unnecessary ingredients,^1,2,3,4 leaving only the active neurotoxin with two supporting ingredients that are not immune triggering. Xeomin has shown zero toxin resistance in pivotal clinical studies.^6,7,8

• As the number one researched biostimulator in Regenerative Aesthetics publications, RADIESSE’s high quality microspheres activate via non-inflammatory pathways. ^9,10,11 RADIESSE utilizes an ingredient that is also naturally found in your body to activate your skin’s regenerative power- boosting collagen, elastin, and other key proteins.^12,13,14 It has been shown to stimulate up to 23 times more collagen and 96% more elastin.^9*

“China’s medical aesthetics community is rapidly evolving, and we are honored to support customers and their patients with advanced, clinically proven solutions for their dynamic needs,” said Lawrence Siow, President of Merz Aesthetics Asia Pacific. “Our commitment in China goes beyond products. We invest in education, training and true partnerships to help practitioners deliver customized results and empower patients to feel confident.”

Merz Aesthetics exists to fuel confidence by helping people look better, feel better and live better around the world. Findings from its recent Pillars of Confidence Global Study reinforce the cultural embrace of aesthetics in China, with 68% of study respondents saying they have had an aesthetic treatment, versus 35% of U.S. respondents. As a premier business partner to customers and their patients, Merz Aesthetics combines the latest technology with top-tier education and training to support customers in their drive to help their patients achieve the outcomes they want.

About Merz Aesthetics

Merz Aesthetics is a medical aesthetics business with a long history of empowering health care professionals, patients and employees to live every day with confidence. We aim to help people around the world look, feel and live like the best versions of themselves — however they define it. Clinically proven, its product portfolio includes injectables, devices, and skin care treatments designed to meet each patient’s needs with high standards of safety and efficacy. Being family owned for more than 115 years, Merz Aesthetics is known for building unique connections with customers who feel like family. Merz Aesthetics’ global headquarters is in Raleigh, N.C., USA, with a commercial presence in 90 countries worldwide. It is also a part of Merz Group, which was founded in 1908 and is based in Frankfurt, Germany. Learn more at merzaesthetics.com.

XEOMIN Important Consumer Safety Information

For Full Prescribing Information including BOXED WARNING and Medication Guide, visit www.xeominaesthetic.com.

Xeomin® (incobotulinumtoxinA) is an FDA-approved treatment to temporarily improve the look of moderate to severe upper facial lines (frown lines, forehead lines, and crow’s feet) in adults. Ask your doctor about Xeomin. The effects of Xeomin may spread hours to weeks after injection causing serious symptoms. Alert your doctor right away as difficulty swallowing, speaking, breathing, eye problems or muscle weakness can be a sign of a life-threatening condition. Swallowing problems may last for several months. Side effects may include allergic reactions or injection site pain, eyelid drooping, and swelling. These are not all the possible side effects of XEOMIN. You may report side effects to FDA at 1-800-FDA-1088.

Xeomin is available by prescription only.

Intended for US audiences only.

IMPORTANT RADIESSE® and RADIESSE® (+) SAFETY INFORMATION

RADIESSE® and RADIESSE® (+) are FDA-approved to smooth moderate to severe facial wrinkles and folds, such as nasolabial folds. RADIESSE (+) is also FDA-approved to improve moderate to severe loss of jawline contour in adults over the age of 21. RADIESSE® is also used for correcting volume loss in the back of the hands. Do not use RADIESSE and RADIESSE (+) if you have severe allergies with anaphylaxis, known hypersensitivity to any of the components, bleeding disorders, or a known hypersensitivity to lidocaine or anesthetics of the amide type. Delayed-onset inflammation at the site of injection following illness, infection, vaccinations, or dental procedures is a known side effect of dermal fillers. Common side effects seen in clinical studies of RADIESSE or RADIESSE (+) include bruising, redness, swelling, pain, itching, lumps/bumps at site of injection, difficulty chewing and other local side effects. These are not all the possible side effects with RADIESSE and RADIESSE (+). RADIESSE is available by prescription only – so ask your provider if RADIESSE is right for you. Please see the Patient Information Guide at www.radiesse.com for a list of these events and full safety information.

References

1. Hefter H, et al. BMJ Open. 2012 Aug 4;2(4):e000646.
2. Dressler D. Eur J Neurol. 2012;19(3):385-389.
3. Frevert J. Drugs R D. 2010;10(2):67-73.
4. Park JY, Sunga O, Wanitphakdeedecha R, Frevert J. Neurotoxin Impurities: A Review of Threats to Efficacy. Plast Reconstr Surg Glob Open. 2020 Jan 24;8(1):e2627. doi: 10.1097/GOX.0000000000002627. PMID: 32095419; PMCID: PMC7015620.
5. Sattler, S.; Gollomp, S.; Curry, A. A Narrative Literature Review of the Established Safety of Human Serum Albumin Use as a Stabilizer in Aesthetic Botulinum Toxin Formulations Compared to Alternatives. Toxins 2023, 15, 619. https://doi.org/10.3390/toxins15100619
6. XEOMIN® [Package insert]. Raleigh, NC: Merz Pharmaceuticals, LLC.
7. BOCOUTURE® (incobotulinumtoxinA) Summary of Product Characteristics. Merz Pharmaceuticals GmbH.
8. Martin MU, Frevert J, Tay CM. Complexing Protein-Free Botulinum Neurotoxin A Formulations: Implications of Excipients for Immunogenicity. Toxins (Basel). 2024 Feb 10;16(2):101. doi: 10.3390/toxins16020101. PMID: 38393178; PMCID: PMC10892905.
9. Data on file
10. McCarthy AD, Hartmann C, et al. A morphological analysis of calcium hydroxylapatite and poly-l-lactic acid biostimulator particles. Skin Res Technol 2024;30(6):e13764.
11. Nowag B, et al. Calcium hydroxylapatite microspheres activate fibroblasts through direct contact to stimulate neocollagenesis. Journal of Cosmetic Dermatology 2022;22(2):426-432
12. Aguilera SB, McCarthy A, Khalifian S et al. The Role of Calcium Hydroxylapatite (Radiesse) as a Regenerative Aesthetic Treatment: A Narrative Review. Aesthetic Surgery Journal 2023;43:1063–90.
13. González N, Goldberg DJ. Evaluating the Effects of Injected Calcium Hydroxylapatite on Changes in Human Skin Elastin and Proteoglycan Formation. Dermatol Surg 2019;45:547–51.
14. Yutskovskaya YA, Alexandrovna E. Improved Neocollagenesis and Skin Mechanical Properties After Injection of Diluted Calcium Hydroxylapatite in the Neck and Décolletage:A Pilot Study. Journal of Drugs in Dermatology 2017;1:68–74.

*Based on 6-month human tissue study vs. placebo

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