Immunome Publishes Preclinical Research Demonstrating that Inhibition of IL-38 Using an Antibody Leads to Anti-Tumor Activity

Immunome, Inc. (Nasdaq: IMNM), a biopharmaceutical company utilizing a proprietary human memory B cell platform to discover and develop antibody therapeutics to improve patient care, today announced the publication of data highlighting efficacy of its preclinical IL-38 blocking antibody, titled “IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation,” in the peer-reviewed journal mAbs. The data in the article demonstrates that antibody-based targeting of IL-38 reactivates the immunostimulatory anti-tumor mechanisms within the tumor microenvironment in preclinical testing.

“Although immune checkpoint inhibitors have transformed how we treat cancer, these therapies are only effective in a small subset of patients. This highlights a significant need for continued innovation in this space,” said Matthew Robinson, Ph.D., Chief Technology Officer of Immunome. “Our Discovery Engine identified IL-38 as a potentially interesting immuno-oncology target. Based on our work highlighting the antitumor activity associated with targeting this novel cytokine and its marked expression across a range of cancers, including head and neck, lung, gastroesophageal, and others, we believe targeting IL-38 could benefit a number of patients.”

Key highlights from the study are:

• IL-38 is expressed across all stages of disease in a range of tumors of high unmet medical need
• An anti-IL-38 antibody, identified by Immunome, inhibits tumor growth in two in-vivo preclinical cancer models
• Treatment in these models with the IL-38 blocking antibody resulted in increased levels of intra-tumoral chemokines
• Animals whose tumors fully resolved, when rechallenged, are resistant to tumor growth, suggesting the induction of immunological memory

Purnanand Sarma, Ph.D., President and Chief Executive Officer of Immunome, added, “These initial preclinical results support both the continued development and the approach we have taken in our patent filings for our anti-IL-38 program. We remain committed to leveraging the full power of our technology platform to continue advancing new and potentially transformative options for cancer patients.”

About Immunome

Immunome is a biopharmaceutical company that utilizes its proprietary human memory B cell platform to discover and develop antibody therapeutics to improve patient care. The company’s focus is on discovering and developing therapeutics in oncology internally and in collaboration with our partners. For more information, please visit www.immunome.com or follow us on Twitter and LinkedIn.

About Immunome’s Discovery Engine

Immunome’s proprietary Discovery Engine identifies novel therapeutic antibodies and their targets through an unbiased interrogation of human memory B cells, highly educated components of the immune system, isolated from patients. Memory B cells are key elements in the human immune system response to disease as they produce specific, high-affinity antibodies that bind to cancer antigens or pathogens. Immunome’s Discovery Engine incorporates high-throughput screening to enable efficient, unbiased, broad, and deep functional evaluation of patient memory B cell repertoires to identify antibodies directed at novel targets. The functional data we generate differentiates our approach from those that use deep sequencing of B cells to identify dominant clones that are common within and across patients and assumes genomic dominance is a hallmark of therapeutic utility.

Forward-Looking Statements

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