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Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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BostonGene Announces Publication in Collaboration with National Cancer Institute and National Institute of Allergy and Infectious Diseases in Cancer Cell

By: via Business Wire

Study underscores the value of a multi-omic approach to examine cell-intrinsic and -extrinsic factors governing progression and therapeutic outcomes in follicular lymphoma patients in a prospective clinical trial

BostonGene, a leading provider of AI-driven molecular and immune profiling solutions, today announced the publication of the manuscript, “Multi-omic Profiling of Follicular Lymphoma Reveals Changes in Tissue Architecture and Enhanced Stromal Remodeling in High-Risk Patients” in Cancer Cell, a premier peer-reviewed scientific journal that publishes high-impact results in cancer research and oncology.

Follicular lymphoma (FL), an often incurable malignancy, stems from developmentally blocked germinal center B cells. Throughout its progression, FL tumor B cells undergo significant genetic changes and extensively remodel the lymphoid microenvironment to promote survival and immune evasion. The dynamic interaction between tumor B cells and the tumor microenvironment are thought to influence the diverse clinical behaviors observed among FL patients, ranging from an indolent disease to a more aggressive clinical course characterized by progression after therapy, histologic transformation, and premature death from lymphoma. Despite the urgent need, current clinical tools inadequately predict disease behavior, underscoring the necessity for risk stratification methods, particularly for early relapsers.

The study, led by researchers at the National Institute of Allergy and Infectious Diseases and National Cancer Institute in collaboration with BostonGene, employed a multi-modal approach to comprehensively examine cell-intrinsic and -extrinsic factors governing disease progression and therapeutic outcomes in FL patients enrolled in a prospective clinical trial. Utilizing BostonGene’s advanced end-to-end bioinformatics and proprietary software, the researchers identified several tumor-specific features and microenvironmental patterns associated with early relapse, the most high-risk subgroup of FL patients.

The research's key findings included identifying unique histological patterns such as stromal desmoplasia and follicular growth pattern alterations observed before first progression and relapse in FL patients. Additional results provide a comprehensive characterization of the genomic and transcriptomic landscapes of tumor B cells, uncovering diverse genetic lesions and alterations in pathways associated with immune escape, apoptosis resistance, and extracellular matrix remodeling. Utilizing single-cell resolution profiling, the research revealed distinct populations of B cells, T cells, myeloid cells, and stromal cells within FL lymph nodes, shedding light on their spatial distribution within the tumor microenvironment. Moreover, the researchers established a correlation between gene signatures linked to poor prognosis and extracellular matrix remodeling with cellular communities identified in FL lymph nodes, offering potential therapeutic targets for high-risk patients.

"The insights garnered from this study signal a pivotal moment in refining treatment strategies for follicular lymphoma patients," said Nathan Fowler, MD, Chief Medical Officer at BostonGene. "By unraveling the intricate molecular and cellular dynamics steering disease progression, we advance toward implementing precision medicine paradigms that can reshape the standard of care.”

Research reported in this press release was supported by the National Institute of Allergy and Infectious Diseases and National Cancer Institute, parts of the National Institutes of Health, under award numbers Z01 AI000545, ZIA BC011914, Z01 SC004024, and Z01 BC011006. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About BostonGene Corporation

BostonGene has a mission to provide transformative, AI-integrated molecular analytics and biomarker discovery for precision matching of therapies to improve the lives of patients living with cancer and other immune-related diseases. BostonGene’s concierge-service model provides customized client solutions using a multi-omic approach prioritized for real-world impact to optimize standard-of-care therapies, accelerate research and provide cost-effective, measurable data-driven results. BostonGene’s tests reveal key drivers of each patient’s unique disease profile, including an in-depth profile of the immune microenvironment, actionable mutations, biomarkers of response to diverse therapies, and recommended therapies. Through these comprehensive analyses, BostonGene’s tests generate a personalized roadmap for therapeutic decision-making for each patient. For more information, visit BostonGene at http://www.BostonGene.com.

"By unraveling the intricate molecular and cellular dynamics steering disease progression, we advance toward implementing precision medicine paradigms that can reshape the standard of care.”

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