Lyra Health Publishes 20th Peer-Reviewed Study, Advancing the Future of Research-Driven Workplace Mental Health

March 18, 2025 at 12:00 PM EDT

Four New Studies Demonstrate Lyra Care Outperforms Typical Therapy in Improving Employee Mental Health and Delivering ROI for Employers

Lyra Health, the leading provider of innovative Workforce Mental Health solutions for employers and health plans, today announced that its research arm, Lyra Clinical Research, has published its 20th peer-reviewed paper. This milestone reinforces Lyra’s unmatched commitment to advancing innovation while delivering effective, evidence-based mental health care that drives lasting results and measurable value for employers. Additionally, the new research highlights Lyra's ability to deliver long-term outcomes and significant improvements for individuals with complex mental health needs.

Leading the research in tech-enabled mental health

Lyra’s proprietary care delivery model, Lyra Care, combines evidence-based therapy or coaching with personalized support between live sessions. Using clinically validated digital tools—such as educational videos, interactive exercises, and messaging—Lyra’s network of evidence-based providers helps employees develop, practice and retain mental health skills. This comprehensive approach is proven to help nine out of 10 people get better.

Lyra is available to nearly 20 million people worldwide and the company has delivered more than 10 million mental health care sessions since its inception in 2015. With this scale, Lyra has developed an extensive data set that offers unparalleled insights into tech-enabled mental health. By analyzing de-identified, aggregated real-world data from various clinical programs, employment sectors, and demographic groups, Lyra Clinical Research has become a leading publisher of large-scale studies on tech-enabled mental health. The company regularly shares its findings to communicate its clinical results and help advance evidence-based mental health care.

“For over seven years, we’ve been building an innovative care model grounded in science to strengthen clients’ progress outside of live sessions,” said Dr. Anita Lungu, Vice President of Clinical Product and Research at Lyra Health. “Our peer-reviewed research highlights the effectiveness of Lyra’s approach in delivering lasting mental health outcomes and tangible value to employers. By offering evidence-based, culturally responsive care, we help people avoid costly, ineffective treatments, setting a new standard for workplace mental health.”

New Studies From Lyra Clinical Research

Lyra Clinical Research recently had four peer-reviewed studies examining the impact of Lyra Care published by PLOS One, JMIR, Nature’s Scientific Reports, and Internet Interventions. These studies further validate the effectiveness of Lyra’s care delivery model and contribute to the growing body of evidence supporting its impact.

Key findings from the newest published peer-reviewed studies include:

Therapeutic Alliance Drives Better Outcomes: Lyra Care clients establish exceptionally strong alliances with their providers—alliances that are central to driving meaningful changes in therapy. This study examines the associations between therapeutic alliance and anxiety and depression symptom trajectories. The findings demonstrate that Lyra’s commitment to creating more personalized, engaged therapeutic experiences including alignment on therapy goals and tasks leads to stronger provider-client relationships and better long-term outcomes (PLOS One).
Guided Practice Sessions Boost Care Effectiveness: Guided Practice Sessions (GPS) are a key component of Lyra’s unique care delivery model, empowering clients to apply what they learn in therapy to their daily lives through digital lessons and exercises, and provider collaboration. This study examines data from over 33,000 clients and reveals that GPS, when combined with live therapy sessions, amplifies the effectiveness of care beyond the effect of live session alone to drive exceptional clinical results—87% of clients who engaged in Lyra Care saw clinical improvement (JMIR).
Lyra Care Reduces Post-traumatic Stress Disorder Symptoms: Post-traumatic stress disorder (PTSD) is one of the most challenging clinical conditions faced by clients. This groundbreaking study demonstrates that Lyra’s comprehensive and specialized care model provides exceptional outcomes for those with the most complex mental health needs—83% of clients with PTSD symptoms experienced clinical improvement (Nature's Scientific Reports).
Long-Term Outcomes After Lyra Care Therapy: A core component of Lyra’s care delivery model is teaching clients new skills they can continue to practice on their own to ensure positive effects continue after treatment has ended. This study examines the long-term impact of Lyra Care therapy and found that clients who engaged in therapy saw clinical improvement rates of 81%+ that were sustained for up to a year, even without any additional therapy (Internet Interventions).

For more information about Lyra Care, visit Lyra’s blog here. To learn more about Lyra Clinical Research, visit Lyra’s website here.

About Lyra Health

Lyra Health is the leading provider of Workforce Mental Health benefits, available to nearly 20 million people globally. Lyra is transforming access to life-changing mental health care using AI-powered provider matching, personalized support, and a digital platform to deliver evidence-based support for individuals and teams. Lyra quickly connects members to the largest dedicated global network of evidenced-based mental health providers and well-being tools, to address every mental health need and deliver outstanding positive outcomes that are equitable across diverse racial and ethnic groups. Extensive peer-reviewed published research confirms Lyra’s transformative care model helps people recover twice as fast and a 26% reduction in overall health care claims costs for participants annually. For more information about Lyra Health’s Workforce Mental Health benefits for employers, visit lyrahealth.com.