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Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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Argonne Leverages AI and Supercomputing to Revolutionize Cancer Research

By: via Business Wire

Discovering new drugs to treat cancer and predicting how tumors will respond to them remain key challenges in the fight against the disease.

At the U.S. Department of Energy’s (DOE) Argonne National Laboratory, researchers are using the power of artificial intelligence (AI) and high performance computing (HPC) to pioneer new methods that speed up drug discovery and enhance drug response prediction. Over the past decade, their efforts have evolved from creating AI tools for cancer research to evaluating the growing number of AI models, ultimately leading to their latest work aimed at drug-resistant cancer targets.

Using the new Aurora exascale system, researchers led an early science project that focused on AI-driven drug discovery for cancer. Their work demonstrated how the system’s immense processing power can help accelerate the discovery of promising new drug molecules.

A decade of AI-driven innovation

The origins of Argonne’s AI-driven cancer research date back to 2016, when DOE forged a partnership with National Cancer Institute (NCI) to employ advanced computing technologies in the fight against cancer. Argonne has been a key player in this collaboration, developing software and AI tools to accelerate progress in cancer research.

A cornerstone of this effort was the CANcer Distributed Learning Environment (CANDLE) project. Led by Argonne’s Rick Stevens and supported by DOE’s Exascale Computing Project, CANDLE’s goal was to develop a scalable deep learning software stack for the nation’s exascale supercomputers.

With that foundation, the lab’s focus extended from building AI models to developing a rigorous method to assess the growing number of models emerging from the broader cancer research community.

This shift led to the launch of the IMPROVE (Innovative Methodologies and New Data for Predictive Oncology Model Evaluation) project in 2021. Led by Argonne in collaboration with Frederick National Laboratory for Cancer Research, the IMPROVE team set out to develop a standardized way to analyze and compare the performance of various drug response prediction models.

While the team’s efforts are laying the groundwork for more reliable and effective AI models, the project continues to evolve to meet new challenges as they emerge.

The next frontier: ​“undruggable” targets

Expanding on the DOE-NCI efforts, researchers are now setting their sights on a longstanding challenge in cancer research: ​“undruggable” targets (proteins that are known to resist chemical treatments).

With a focus on proteins that play a key role in cancer progression, the team’s work begins with a list of targets identified through lab experiments. The researchers then retrieve the protein sequences from public databases. If a protein’s 3D structure is unknown, they work with scientists at the Advanced Photon Source (APS), a DOE Office of Science user facility, to determine it. The APS was recently upgraded to deliver significantly brighter X-ray beams, giving scientists a powerful tool to advance research across different fields.

After determining the protein’s structure, the team turns to Aurora to simulate the behavior and interactions of the protein at the atomic level. The simulations combined with experimental data help identify areas where small molecules might bind to inhibit the protein’s activity.

The computational results are then relayed to experimental collaborators to validate the findings. Adding to the challenge is the team’s focus on undruggable targets. Inhibiting these proteins has eluded researchers for decades, earning them a reputation as one of the most difficult problems in cancer biology.

Contacts

Christopher J. Kramer

Head of Media Relations

Argonne National Laboratory

Office: 630.252.5580

Email: media@anl.gov

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