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Our mission: Bringing practical business and technical intelligence to today's structured cabling professionals

For more than 30 years, Cabling Installation & Maintenance has provided useful, practical information to professionals responsible for the specification, design, installation and management of structured cabling systems serving enterprise, data center and other environments. These professionals are challenged to stay informed of constantly evolving standards, system-design and installation approaches, product and system capabilities, technologies, as well as applications that rely on high-performance structured cabling systems. Our editors synthesize these complex issues into multiple information products. This portfolio of information products provides concrete detail that improves the efficiency of day-to-day operations, and equips cabling professionals with the perspective that enables strategic planning for networks’ optimum long-term performance.

Throughout our annual magazine, weekly email newsletters and 24/7/365 website, Cabling Installation & Maintenance digs into the essential topics our audience focuses on.

  • Design, Installation and Testing: We explain the bottom-up design of cabling systems, from case histories of actual projects to solutions for specific problems or aspects of the design process. We also look at specific installations using a case-history approach to highlight challenging problems, solutions and unique features. Additionally, we examine evolving test-and-measurement technologies and techniques designed to address the standards-governed and practical-use performance requirements of cabling systems.
  • Technology: We evaluate product innovations and technology trends as they impact a particular product class through interviews with manufacturers, installers and users, as well as contributed articles from subject-matter experts.
  • Data Center: Cabling Installation & Maintenance takes an in-depth look at design and installation workmanship issues as well as the unique technology being deployed specifically for data centers.
  • Physical Security: Focusing on the areas in which security and IT—and the infrastructure for both—interlock and overlap, we pay specific attention to Internet Protocol’s influence over the development of security applications.
  • Standards: Tracking the activities of North American and international standards-making organizations, we provide updates on specifications that are in-progress, looking forward to how they will affect cabling-system design and installation. We also produce articles explaining the practical aspects of designing and installing cabling systems in accordance with the specifications of established standards.

Cabling Installation & Maintenance is published by Endeavor Business Media, a division of EndeavorB2B.

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1ST Biotherapeutics Announces Clinical Trial Collaboration and Supply Agreement with MSD to Evaluate FB849 in Combination With KEYTRUDA® (pembrolizumab)

YONGIN, South Korea, September 19, 2023 -- 1ST Biotherapeutics, Inc., a clinical-stage biotechnology company focused on the development of novel small molecule therapeutics in neurodegenerative diseases, immuno-oncology, and rare diseases, today announced a Clinical Trial Collaboration and Supply Agreement (CTCSA) with MSD, a tradename of Merck & Co., Inc., Rahway, NJ, USA, to evaluate FB849 in combination with MSD’s anti-PD-1 therapy KEYTRUDA® (pembrolizumab) in a Phase I/II clinical trial for the treatment of patients with advanced solid tumors.

Under the terms of the agreement, MSD will provide KEYTRUDA to be used in combination with FB849 for the planned Phase I/II study.

“We are very pleased to mark the next stage of FB849’s development with this exciting collaboration. We are hopeful that combining FB849 with KEYTRUDA may induce an effective anti-tumor response and show an additive benefit for patients with advanced solid tumors,” said Jamie Jae Eun Kim, Ph.D., Founder and Chief Executive Officer of 1ST Biotherapeutics. “This collaboration will play an important role in the advancement of this program and marks further validation of our differentiated drug discovery and development approach. We will continue to leverage our expertise and dedication to bring innovative therapeutics to patients with high unmet medical needs.”

The Phase I/II study (NCT05761223) is a first-in-human, multicenter, open-label study to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of FB849 alone as a monotherapy and in combination with KEYTRUDA for the treatment of advanced solid tumors. The recruitment in the clinical study is expected in the second half of 2023.

KEYTRUDA® is a registered trademark of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., Rahway, NJ, USA.

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About FB849

FB849 is a 1ST Biotherapeutic’s proprietary small molecule inhibitor of hematopoietic progenitor kinase 1 (HPK1) as a novel next-generation immuno-oncology agent. Throughout the preclinical studies, it has been demonstrated that FB849’s highly selective inhibition of HPK1 induces potent anti-cancer immunity via cross-spectrum immune cell invigoration, including T cells, B cells, dendritic cells, and macrophages, with robust and durable effects in tumor growth inhibition.

About 1ST Biotherapeutics

1ST Biotherapeutics is a science-driven biopharmaceutical company focused on the development of breakthrough therapies in neurodegenerative diseases, immuno-oncology, and rare diseases. Founded in 2016, 1ST Biotherapeutics has rapidly developed a deep pipeline of first-in-class investigational therapeutics with clear mechanisms for proper disease modification and excellent pharmacological properties. 1ST Biotherapeutics is based in Yongin, South Korea.

For more information, please visit 1stbio.com.

Contact 1ST Biotherapeutics, Inc.
info@1stbio.com
Tel. +82 31 8023 5332

Media Inquiries
akampion
Dr. Ludger Wess / Ines-Regina Buth
Managing Partners
info@akampion.com

Tel. +49 40 88 16 59 64 /Tel. +49 30 23 63 27 68



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