Laser Focus World is an industry bedrock—first published in 1965 and still going strong. We publish original articles about cutting-edge advances in lasers, optics, photonics, sensors, and quantum technologies, as well as test and measurement, and the shift currently underway to usher in the photonic integrated circuits, optical interconnects, and copackaged electronics and photonics to deliver the speed and efficiency essential for data centers of the future.

Our 80,000 qualified print subscribers—and 130,000 12-month engaged online audience—trust us to dive in and provide original journalism you won’t find elsewhere covering key emerging areas such as laser-driven inertial confinement fusion, lasers in space, integrated photonics, chipscale lasers, LiDAR, metasurfaces, high-energy laser weaponry, photonic crystals, and quantum computing/sensors/communications. We cover the innovations driving these markets.

Laser Focus World is part of Endeavor Business Media, a division of EndeavorB2B.

Laser Focus World Membership

Never miss any articles, videos, podcasts, or webinars by signing up for membership access to Laser Focus World online. You can manage your preferences all in one place—and provide our editorial team with your valued feedback.

Magazine Subscription

Can you subscribe to receive our print issue for free? Yes, you sure can!

Newsletter Subscription

Laser Focus World newsletter subscription is free to qualified professionals:

The Daily Beam

Showcases the newest content from Laser Focus World, including photonics- and optics-based applications, components, research, and trends. (Daily)

Product Watch

The latest in products within the photonics industry. (9x per year)

Bio & Life Sciences Product Watch

The latest in products within the biophotonics industry. (4x per year)

Laser Processing Product Watch

The latest in products within the laser processing industry. (3x per year)

Get Published!

If you’d like to write an article for us, reach out with a short pitch to Sally Cole Johnson: [email protected]. We love to hear from you.

Photonics Hot List

Laser Focus World produces a video newscast that gives a peek into what’s happening in the world of photonics.

Following the Photons: A Photonics Podcast

Following the Photons: A Photonics Podcast dives deep into the fascinating world of photonics. Our weekly episodes feature interviews and discussions with industry and research experts, providing valuable perspectives on the issues, technologies, and trends shaping the photonics community.

Editorial Advisory Board

  • Professor Andrea M. Armani, University of Southern California
  • Ruti Ben-Shlomi, Ph.D., LightSolver
  • James Butler, Ph.D., Hamamatsu
  • Natalie Fardian-Melamed, Ph.D., Columbia University
  • Justin Sigley, Ph.D., AmeriCOM
  • Professor Birgit Stiller, Max Planck Institute for the Science of Light, and Leibniz University of Hannover
  • Professor Stephen Sweeney, University of Glasgow
  • Mohan Wang, Ph.D., University of Oxford
  • Professor Xuchen Wang, Harbin Engineering University
  • Professor Stefan Witte, Delft University of Technology

Crown Bioscience Introduces OrganoidXplore: Revolutionizing Cancer Research with Rapid Large-scale Organoid Drug Screening

Crown Bioscience, a global contract research organization (CRO) and JSR Life Sciences company, today announced the launch of its ground-breaking service offering, OrganoidXploreTM. This large-scale organoid panel screening platform promises robust, reproducible, and clinically relevant output at record speed, accelerating preclinical oncology drug discovery by empowering researchers and reshaping the landscape of cancer treatment development.

Screening of a large panel of patient-derived organoids is enabled using Crown Bioscience’s unique assay-ready (AR) organoid technology. Recent posters presented at the AACR annual meeting and ANE international conference 2023 demonstrate the performance of assay-ready organoids against freshly prepared organoids – the traditional methodology. The study demonstrated the utility of OrganoidXplore and revealed:

  • Highly Robust Performance: Both the assay-ready and original methods consistently performed with high accuracy across multiple assays.
  • Accelerated Timelines and Reduced Costs: OrganoidXplore slashed project timelines by two-thirds, when compared to standard methods.
  • Reliable and Reproducible Drug Response Comparisons: Both methods showed analogous results in cell viability (CTG) and high content imaging (HCI) assays when tested with standard drugs such as paclitaxel, carboplatin, and cisplatin.

OrganoidXplore transcends traditional 2D cell culture systems in terms of patient relevance, heralding a significant leap in preclinical drug screening. By accurately replicating the genomic, morphological, and pathophysiological attributes of original tumors, researchers are now equipped to screen against an extensive range of predictive models. Results can be obtained within an expedited timeframe of just six weeks, magnifying research speed three-fold and anchoring its promise on the robustness and reproducibility of its advanced assay-ready technology.

Researchers can choose between a comprehensive Full Panel or a specialized KRAS Panel to meet their specific goals. The Full Panel currently comprises 50 organoid models covering seven cancer indications, which are also available as companion Patient-Derived Xenografts (PDX). The KRAS Panel specifically targets four cancer indications, with 25 models covering a broad range of KRAS mutations. These models are also available as PDX, allowing for a seamless transition to follow-on studies.

In combination with comprehensive next-generation sequencing (NGS) characterization, including whole exome sequencing (WES) and RNA sequencing (RNAseq), OrganoidXplore enables expedited biomarker identification, highly relevant mechanism of action studies, selection of indications and/or models, investigation of drug repurposing, and improved patient stratification.

Leo Price, PhD, Senior Vice President, In Vitro and Head of Crown Bioscience Netherlands, said: “OrganoidXplore addresses the exacting demands of pioneering research initiatives by offering a diverse selection of models that cover a wide spectrum of genetic backgrounds and mutations. Thanks to the implementation of innovative organoid cryopreservation technology automation and assay automation, OrganoidXplore’s precision, speed, and reproducibility are unrivaled.”

Crown Bioscience remains steadfast in its commitment to driving innovations in oncology research, evidenced by the introduction of OrganoidXplore, designed with the mission to accelerate drug discovery.

###

About Crown Bioscience

Crown Bioscience, a JSR Life Sciences company, is a global CRO that provides preclinical and translational platforms to help our customers advance their research and development in oncology and immuno-oncology. We are the exclusive preclinical CRO to offer tumor organoid services with the well-established Hubrecht Organoid Technology, offering over 600 organoid models spanning 22 cancer indications. In addition, we have developed the largest commercially available PDX collection in the world. We focus on helping our customers develop novel therapies to maximize the chances that patients receive the right treatment at the right time. Founded in 2006, Crown Bioscience has 13 facilities across the United States, Europe, and Asia.

For more information or to get in touch, please visit www.crownbio.com

Contacts

Stock Quote API & Stock News API supplied by www.cloudquote.io
Quotes delayed at least 20 minutes.
By accessing this page, you agree to the following
Privacy Policy and Terms Of Service.