Laser Focus World is an industry bedrock—first published in 1965 and still going strong. We publish original articles about cutting-edge advances in lasers, optics, photonics, sensors, and quantum technologies, as well as test and measurement, and the shift currently underway to usher in the photonic integrated circuits, optical interconnects, and copackaged electronics and photonics to deliver the speed and efficiency essential for data centers of the future.

Our 80,000 qualified print subscribers—and 130,000 12-month engaged online audience—trust us to dive in and provide original journalism you won’t find elsewhere covering key emerging areas such as laser-driven inertial confinement fusion, lasers in space, integrated photonics, chipscale lasers, LiDAR, metasurfaces, high-energy laser weaponry, photonic crystals, and quantum computing/sensors/communications. We cover the innovations driving these markets.

Laser Focus World is part of Endeavor Business Media, a division of EndeavorB2B.

Laser Focus World Membership

Never miss any articles, videos, podcasts, or webinars by signing up for membership access to Laser Focus World online. You can manage your preferences all in one place—and provide our editorial team with your valued feedback.

Magazine Subscription

Can you subscribe to receive our print issue for free? Yes, you sure can!

Newsletter Subscription

Laser Focus World newsletter subscription is free to qualified professionals:

The Daily Beam

Showcases the newest content from Laser Focus World, including photonics- and optics-based applications, components, research, and trends. (Daily)

Product Watch

The latest in products within the photonics industry. (9x per year)

Bio & Life Sciences Product Watch

The latest in products within the biophotonics industry. (4x per year)

Laser Processing Product Watch

The latest in products within the laser processing industry. (3x per year)

Get Published!

If you’d like to write an article for us, reach out with a short pitch to Sally Cole Johnson: [email protected]. We love to hear from you.

Photonics Hot List

Laser Focus World produces a video newscast that gives a peek into what’s happening in the world of photonics.

Following the Photons: A Photonics Podcast

Following the Photons: A Photonics Podcast dives deep into the fascinating world of photonics. Our weekly episodes feature interviews and discussions with industry and research experts, providing valuable perspectives on the issues, technologies, and trends shaping the photonics community.

Editorial Advisory Board

  • Professor Andrea M. Armani, University of Southern California
  • Ruti Ben-Shlomi, Ph.D., LightSolver
  • James Butler, Ph.D., Hamamatsu
  • Natalie Fardian-Melamed, Ph.D., Columbia University
  • Justin Sigley, Ph.D., AmeriCOM
  • Professor Birgit Stiller, Max Planck Institute for the Science of Light, and Leibniz University of Hannover
  • Professor Stephen Sweeney, University of Glasgow
  • Mohan Wang, Ph.D., University of Oxford
  • Professor Xuchen Wang, Harbin Engineering University
  • Professor Stefan Witte, Delft University of Technology

As Tiziana Life Sciences (NASDAQ: TLSA) Prepares For Phase 2 Trials, Have They Successfully Derisked Foralumab?

--News Direct--

By David Willey, Benzinga

Tiziana Life Sciences, Inc. (NASDAQ: TLSA) reports that its upcoming phase 2 trial for lead candidate foralumab’s treatment of non-active Secondary Progressive Multiple Sclerosis (na-SPMS) has already been derisked, given the results from its expanded access program.

Developing innovative drugs can be a lengthy, risky process, as there are numerous unknowns that a company has to be prepared for. De-risking in drug development trials involves an early accumulation of as much information about the product as possible and can be an important strategy for companies to reduce unknown variables for future trials. De-risking can tell the company the drug’s safety profile, how its mechanism of action works and what benchmarks to measure going forward. Tiziana has completed its expanded access program for foralumab, and the drug has already demonstrated a robust safety profile and improved the expanded disability status scale (EDSS) score in some patients.

Building A De-Risked Phase 2 Trial

Tiziana will start its phase 2a trial as a multi-center, double-blinded, placebo-controlled trial – administering foralumab to its na-SPMS patients – and it will use the results from its expanded access program as a primary outcome measure.

The company had taken 3-month Positron Emission Tomography (PET) brain scans for the six na-SPMS patients in its Expanded Access program. The chairman of Tiziana's Scientific Advisory Board described the results as “extraordinary,” with five of the six patients demonstrating reduced microglia activation, which suggests possible clinical improvements for the patients.

Foralumab works by targeting regulatory T-cells and crossing the blood-brain barrier to dampen neuroinflammation. Inflammation of the brain is caused by activated microglia – the brain’s immune cells – and drives the neural degeneration associated with MS. Foralumab can downregulate microglia activation, leading to potential improvements in the patient's disability status.

Foralumab is a first-in-class, fully human anti-CD3 monoclonal antibody (mAb), a class of immunotherapy drugs that target the patient’s immune system. Drugs using mAbs are increasingly common, and the global market for mAbs in 2022 was $210.06 billion. Companies looking to develop MS therapies include Sanofi (NASDAQ: SNY) and Bayer (OTC: BAYRY). However, there are currently no drugs approved by the Food and Drug Administration (FDA) for non-active SPMS.

Click here to keep up with developments from Tiziana as it starts phase 2.

This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice.

Contact Details

Benzinga

+1 877-440-9464

info@benzinga.com

Company Website

http://www.benzinga.com

View source version on newsdirect.com: https://newsdirect.com/news/as-tiziana-life-sciences-nasdaq-tlsa-prepares-for-phase-2-trials-have-they-successfully-derisked-foralumab-338407623

Stock Quote API & Stock News API supplied by www.cloudquote.io
Quotes delayed at least 20 minutes.
By accessing this page, you agree to the following
Privacy Policy and Terms Of Service.