Laser Focus World is an industry bedrock—first published in 1965 and still going strong. We publish original articles about cutting-edge advances in lasers, optics, photonics, sensors, and quantum technologies, as well as test and measurement, and the shift currently underway to usher in the photonic integrated circuits, optical interconnects, and copackaged electronics and photonics to deliver the speed and efficiency essential for data centers of the future.

Our 80,000 qualified print subscribers—and 130,000 12-month engaged online audience—trust us to dive in and provide original journalism you won’t find elsewhere covering key emerging areas such as laser-driven inertial confinement fusion, lasers in space, integrated photonics, chipscale lasers, LiDAR, metasurfaces, high-energy laser weaponry, photonic crystals, and quantum computing/sensors/communications. We cover the innovations driving these markets.

Laser Focus World is part of Endeavor Business Media, a division of EndeavorB2B.

Laser Focus World Membership

Never miss any articles, videos, podcasts, or webinars by signing up for membership access to Laser Focus World online. You can manage your preferences all in one place—and provide our editorial team with your valued feedback.

Magazine Subscription

Can you subscribe to receive our print issue for free? Yes, you sure can!

Newsletter Subscription

Laser Focus World newsletter subscription is free to qualified professionals:

The Daily Beam

Showcases the newest content from Laser Focus World, including photonics- and optics-based applications, components, research, and trends. (Daily)

Product Watch

The latest in products within the photonics industry. (9x per year)

Bio & Life Sciences Product Watch

The latest in products within the biophotonics industry. (4x per year)

Laser Processing Product Watch

The latest in products within the laser processing industry. (3x per year)

Get Published!

If you’d like to write an article for us, reach out with a short pitch to Sally Cole Johnson: [email protected]. We love to hear from you.

Photonics Hot List

Laser Focus World produces a video newscast that gives a peek into what’s happening in the world of photonics.

Following the Photons: A Photonics Podcast

Following the Photons: A Photonics Podcast dives deep into the fascinating world of photonics. Our weekly episodes feature interviews and discussions with industry and research experts, providing valuable perspectives on the issues, technologies, and trends shaping the photonics community.

Editorial Advisory Board

  • Professor Andrea M. Armani, University of Southern California
  • Ruti Ben-Shlomi, Ph.D., LightSolver
  • James Butler, Ph.D., Hamamatsu
  • Natalie Fardian-Melamed, Ph.D., Columbia University
  • Justin Sigley, Ph.D., AmeriCOM
  • Professor Birgit Stiller, Max Planck Institute for the Science of Light, and Leibniz University of Hannover
  • Professor Stephen Sweeney, University of Glasgow
  • Mohan Wang, Ph.D., University of Oxford
  • Professor Xuchen Wang, Harbin Engineering University
  • Professor Stefan Witte, Delft University of Technology

BridgeBio (NASDAQ: BBIO) Announces Exceptionally Positive Outcomes in Phase 3 Study of Acoramidis

BridgeBio Pharma (NASDAQ: BBIO), a leading biopharmaceutical company, announced significant outcomes from the ATTRibute-CM, their Phase 3 study of acoramidis, for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM).

Superior Efficacy of Acoramidis Shown in Clinical Trial

The trial recorded a highly statistically significant improvement in the primary endpoint with a Win Ratio of 1.8 (p<0.0001). A meaningful separation was observed across all measures of mortality, morbidity, function, and quality of life. An impressive 81% on-treatment survival rate was achieved as opposed to a 74% survival rate on placebo. Notably, the risk of cardiovascular-related hospitalization was reduced by a significant 50% (p<0.0001) with the acoramidis treatment.

Secondary Endpoints Demonstrate Consistent Treatment Benefit

Treatment benefits were also observed in secondary endpoints such as NT-proBNP, KCCQ, and 6-minute walk distance, all of which showed a highly significant and clinically meaningful improvement at 30 months (p<0.0001).

Comparative Analysis Supports Promising Outcomes of Acoramidis

Post hoc comparative analysis showed that acoramidis resulted in a 42% greater increase in serum TTR levels and a 92% improvement in median NT-proBNP relative to placebo + tafamidis.

Safety and NDA Filing

No safety signals of clinical concern were identified during the trial. Further enhancing the significance of these results, BridgeBio intends to submit a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) by the end of 2023.

Acoramidis Paves the Way for Future Treatment

The ATTRibute-CM trial’s positive results offer new hope for patients with ATTR-CM. As per Dr. Daniel Judge, co-chair of the ATTRibute-CM Steering Committee, the results are truly remarkable. The robust findings confirm the potential of potent TTR stabilization to impact patients’ lives significantly. Acoramidis shows promise as a potent, orally-administered, small molecule stabilizer of transthyretin, positioning BridgeBio at the forefront of genetic diseases and cancers treatment research.

BridgeBio’s Continued Commitment to Research and Development

The filing of the NDA is part of the company’s commitment to develop medicines that target diseases at their source, reflecting BridgeBio’s overall portfolio strategy. Acoramidis has intellectual property protection until at least 2039, ensuring its long-term potential as a groundbreaking treatment option.

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

The post BridgeBio (NASDAQ: BBIO) Announces Exceptionally Positive Outcomes in Phase 3 Study of Acoramidis appeared first on Spotlight Growth.

Stock Quote API & Stock News API supplied by www.cloudquote.io
Quotes delayed at least 20 minutes.
By accessing this page, you agree to the following
Privacy Policy and Terms Of Service.