Aprea Therapeutics, Inc. (Nasdaq: APRE) is a clinical-stage biopharmaceutical company pioneering a new era in precision oncology. By combining deep genetic insight with targeted molecular design, Aprea is advancing therapies that exploit cancer-specific vulnerabilities — aiming to outsmart tumor biology while preserving healthy tissue and improving patient quality of life.

At the center of Aprea’s strategy is its commitment to develop and commercialize novel cancer therapeutics that reactivate or target key cell-cycle regulators, restoring the natural defense mechanisms that cancer cells suppress. The company’s flagship clinical programs include:

• APR-246, a small-molecule reactivator of mutant p53, one of the most frequently altered tumor suppressor proteins in cancer. Currently in late-stage development for hematologic malignancies such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), APR-246 has the potential to become a first-in-class therapy addressing critical unmet needs.
• APR-1051, an oral WEE1 kinase inhibitor currently in Phase 1 clinical evaluation (ACESOT-1051 study) for advanced solid tumors. Early results presented at the AACR-NCI-EORTC conference demonstrate promising signals of disease control in heavily pretreated patients with FBXW7, CCNE1, and KRAS mutations — genetic profiles known to drive tumor progression and therapeutic resistance.
• ATRN-119, a macrocyclic ATR inhibitor designed to target the DNA damage response pathway, broadening Aprea’s precision-oncology portfolio to multiple tumor types.

Aprea’s scientific approach leverages synthetic lethality and DNA damage repair biology, targeting weaknesses unique to cancer cells. This dual-pronged strategy — reactivating tumor suppressors like p53 and inhibiting kinases that regulate DNA replication checkpoints — enables the development of therapeutics with both potency and selectivity. See Report Now!

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“Our mission is to advance a new generation of precision therapies that directly target cancer’s molecular drivers while minimizing toxicity,” said Dr. Philippe Pultar, Senior Medical Advisor at Aprea Therapeutics. “We believe our expanding pipeline of WEE1, ATR, and p53-targeted programs positions Aprea at the forefront of mechanistic, data-driven oncology.”

As the company progresses its ongoing trials into 2026, Aprea Therapeutics (Nasdaq: APRE) stands at a pivotal moment in its evolution — translating cutting-edge science into real-world therapeutic impact. With multiple clinical catalysts on the horizon, Aprea is shaping a future where cancer treatment is guided not by broad toxicity, but by molecular precision and patient-centric innovation.

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