• Clene Inc. reported new preclinical data on its drug candidate CNM-Au8 for Parkinson’s disease.
• The therapy improved mitochondrial health, restored cellular metabolism, reduced inflammation, and normalized gene expression in dopaminergic neurons.
• Findings were presented at the Michael J. Fox Foundation’s H2 Therapeutics Stewardship Meeting in New York City.
• CNM-Au8 previously showed positive energetic and metabolic effects in a Phase 2 Parkinson’s trial, aligning with the new preclinical results.
• The treatment demonstrated no toxicity in neuronal models, consistent with safety data from over 1,000 patient-years in ALS and MS trials.
• Clene plans to design a Phase 2 clinical study for Parkinson’s disease while advancing ALS and MS programs.

Clene (NASDAQ: CLNN) and its wholly owned subsidiary, Clene Nanomedicine Inc., a late clinical-stage biopharmaceutical company focused on improving mitochondrial health and protecting neuronal function to treat neurodegenerative diseases, has presented encouraging preclinical findings for its lead investigational therapy, CNM-Au8, in Parkinson’s disease. The data, announced earlier in September 2025, highlight the drug’s potential to address key cellular and energetic deficits that drive disease progression (https://ibn.fm/EECHU).

The results were unveiled at the Michael J. Fox Foundation’s H2 Therapeutics Stewardship Meeting in New York City. Researchers reported that CNM-Au8 improved mitochondrial health, reduced harmful inflammation, restored energy metabolism, and normalized disrupted gene expression in…

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NOTE TO INVESTORS: The latest news and updates relating to CLNN are available in the company’s newsroom at https://ibn.fm/CLNN

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