Bioceres Crop Solutions Corp. (NASDAQ: BIOX) and the Colorado Wheat Research Foundation (CWRF) today announced a strategic collaboration to jointly develop and commercialize HB4^® wheat in the United States.

The agreement combines Bioceres’ proprietary HB4^® technology, with CWRF’s leadership in U.S. wheat innovation to create a next generation wheat production system. This system is designed to integrate climate resilience and environmentally responsible weed management, delivering greater productivity for growers and improved supply stability for customers.

As part of the collaboration, Bioceres will grant CWRF exclusive, sublicensable rights to the HB4^® trait in the U.S. territory. CWRF will serve as Trait Manager, facilitating broad access to HB4^® wheat for third-party breeding programs and commercial channels, and leading engagement with U.S. stakeholders. The parties will also work together with industry participants to develop, register, and commercialize new broad-spectrum herbicide formulations tailored for HB4^® wheat. These formulations will be developed in combination with Bioceres’ biological solutions, to deliver an advanced, sustainable system that enhances grower performance while promoting environmental safety.

“This collaboration marks a significant step forward for HB4^® wheat in the United States, and aligns with our renewed seed strategy: to focus on our core strength of developing cutting-edge science and to partner with top-tier industry players to bring it to life through breeding and commercialization,” said Federico Trucco, CEO of Bioceres Crop Solutions. “By combining our HB4^® trait platform with CWRF’s industry leadership, we are building the foundation for a next-generation wheat production system that enhances grower profitability and aligns with global sustainability goals.”

“This is an important milestone for the wheat industry and sets the stage for long-term innovation in this important crop,” said Brad Erker, Executive Director at CWRF. “We are proud to support open and inclusive access to HB4^® technology and to lead U.S. stakeholder engagement to ensure its responsible rollout.”

Bioceres will continue to lead all regulatory activities for the HB4^® trait, ensuring full alignment with the U.S. Wheat Industry Principles for Biotechnology Commercialization. This includes securing approvals in key export destinations, establishing tolerance thresholds for low-level presence, and ensuring trait stewardship through detection tools and certified seed systems.

The HB4^® trait will be available to any interested public or private wheat breeding program in the U.S. through an open licensing model — supporting widespread access while upholding high standards of quality, transparency and stewardship.

About Bioceres Crop Solutions (NASDAQ: BIOX)

Bioceres is a fully integrated provider of crop productivity solutions designed to enable the transition to a more sustainable agriculture. The company’s HB4^® technology platform is at the forefront of agricultural innovation in drought tolerance and crop protection.

About Colorado Wheat Research Foundation (CWRF)

CWRF is a farmer-governed nonprofit organization that supports the development and delivery of innovative wheat technologies for the benefit of U.S. wheat growers. Through strategic collaborations, CWRF advances the availability of high-performing wheat varieties and traits to the industry.

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