For years, doctors have known that viral infections can cause inflammation, but recent studies have revealed a more alarming connection: viruses may reawaken "sleeping" cancer cells, leading to a resurgence of metastatic cancer. Now, a clinical-stage drug candidate, NV-387, is showing promise in fighting both viral infections and the inflammation that could trigger cancer's return.
The Unseen Threat of Viral Infections
Recent research has shed light on how viruses, particularly those like SARS-CoV-2 (COVID-19) and Influenza, can increase the risk of metastatic cancer recurrence. Viral infections cause a significant inflammatory response, marked by an increase in cytokines like IL-6. This heightened inflammation can stir dormant cancer cells from their "slumber," allowing them to spread to new parts of the body. This discovery highlights an unmet medical need: a treatment that can not only neutralize the virus but also calm the inflammatory storm it creates.
NV-387: A Dual-Action Solution
Developed by NanoViricides, Inc., (NYSE: NNVC) NV-387 is a unique antiviral drug designed to address both sides of this threat. Its mechanism of action is two-fold:
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Direct Antiviral Action: The drug attacks the virus itself, preventing it from replicating and causing illness. In animal model studies, NV-387 has proven effective against a range of lethal respiratory viruses, including Influenza, RSV, and even coronaviruses. In one study, it protected the lungs of animals with severe Influenza A/H3N2 infection, outperforming existing approved drugs like Tamiflu and Xofluza.
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Anti-Inflammatory Effect: A key finding is that NV-387 treatment significantly reduces inflammatory markers, including IL-6. By taming the body's immune response, the drug may minimize the risk of reactivating dormant cancer cells, offering a potential new line of defense for cancer patients in remission who contract a viral infection.
This dual-action capability positions NV-387 as a potential breakthrough in managing viral infections, especially for vulnerable populations where the stakes are higher than a simple cold or flu.
Answering an Unmet Medical Need
The world faces a constant barrage of viral threats, from the two annual waves of COVID-19 to the seasonal resurgence of Influenza and RSV. Traditional defenses like vaccines and antibodies often struggle to keep up with new variants, leaving a gap in our medical arsenal.
NV-387's broad-spectrum nature means viruses may be unable to escape it, a significant advantage over other treatments. The drug's ability to protect the lungs and reduce inflammation has been demonstrated in multiple animal studies, paving the way for its progression into Phase II clinical trials. If successful, NV-387 could become an essential tool not just for treating viral illnesses but also for protecting cancer patients from the devastating possibility of a cancer recurrence triggered by a simple viral infection. Other notable biotech stocks to keep an eye out include Viking Therapeutics (NASDAQ: VKTX) and Regeneron Pharmaceuticals (NASDAQ: REGN) and Legend Biotech Corporation (NASDAQ: LEGN). VKTX and REGN have faced challenges this year that have sunk their stock prices. The former is down by 37% this year, while the latter has declined 17%. Legend Biotech Corporation (NASDAQ: LEGN) (Legend Biotech) announced today that they will participate in a fireside chat at the Morgan Stanley Global Healthcare Conference in New York, NY on Tuesday, September 9, 2025, at 4:05 p.m. ET.
Sources:
https://finance.yahoo.com/news/drug-could-reduce-metastatic-cancer-123000404.html
https://finance.yahoo.com/news/legend-biotech-participate-morgan-stanley-120000442.html
https://finance.yahoo.com/news/2-biotech-stocks-could-soar-124500482.html
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