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One-Stop Solution for Key Nucleic Acid Extraction Materials

By: AB Newswire

May 25, 2026 at 21:25 PM EDT

ⓘ This article is third-party content and does not represent the views of this site. We make no guarantees regarding its accuracy or completeness.

As the foundation of all molecular biology research, the quality of extracted nucleic acids is one of the key factors determining the success of downstream experiments. In the development of nucleic acid extraction reagents, in addition to conventional chemical components, small molecular nucleic acids and enzymes can greatly improve extraction efficiency and eliminate interference from non-target substances, thus becoming vital ingredients in nucleic acid extraction.

01 Proteinase K

Overview

Proteinase K is a serine protease with high enzymatic activity and broad substrate specificity. It preferentially hydrolyzes ester bonds and peptide bonds adjacent to the C-terminus of hydrophobic, sulfur-containing and aromatic amino acids, and is commonly used to degrade proteins for short peptide preparation. It possesses the typical catalytic triad Asp39-His69-Ser224 characteristic of serine proteases. Two calcium ion binding sites around its active center enhance its stability, enabling it to maintain high enzymatic activity under a wide range of conditions.

Usage

1. Genetic diagnostic kits

2. RNA and DNA extraction kits

3. Extract non-protein components from tissues and degrade protein impurities, such as the preparation of DNA vaccines and heparin

4. Isolation of chromosomal DNA for pulsed-field gel electrophoresis

5. Western blotting

6. R&D and mass production of enzymatic glycated albumin reagents for in vitro diagnostics

Product Introduction

Product Name	Cat.No.	Specification	Storage Condition
Proteinase K (Lyophilized powder)	HYC110	100mg/1g/10g/100g	Can be stored at room temperature with a shelf life of 3 years.
Proteinase K (liquid)	HYC112	1mL/5mL/100mL/1000mL
Proteinase K for NGS (lyophilized powder)	HYC113	100mg/1g/10g/100g
Proteinase K for mNGS (liquid)	HYC114	1mL/5mL/100mL/1000mL

02 DNase I

Overview

Deoxyribonuclease I (DNase I) is an endodeoxyribonuclease capable of digesting single-stranded and double-stranded DNA. It recognizes and cleaves phosphodiester bonds, producing monodeoxyribonucleotides or single/double-stranded oligodeoxyribonucleotides with a phosphate group at the 5'-end and a hydroxyl group at the 3'-end.

Usage

DNase I has an extremely wide range of applications, covering almost all fields involving RNA manipulation.

1. High-sensitivity qRT-PCR

2. Next-generation sequencing (NGS): RNA-Seq library construction

3. In vitro transcription experiments

Product Introduction

Product Name	Cat.No.	Specification	Storage Condition
Recombinant DNase I (RNase-free)	HYC117	0.5KU/5KU/50KU	Store at -20℃ with a shelf life of 2 years.

03 Poly A Carrier RNA

Overview

It is synthesized by polymerizing adenylic acid in vitro with polynucleotide phosphorylase, consisting of a mixture of polyadenylic acids ranging from 100-mer to 10000-mer.

Usage

1. Block surface adsorption Most plastic consumables carry static electricity and tend to adsorb nucleic acids. Poly A saturates these adsorption sites and greatly reduces the loss of target nucleic acids.

2. Inhibit nuclease activity Various nucleases exist in biological samples and experimental environments. Poly A can inactivate trace nucleases during extraction and preservation, improving the yield and stability of target nucleic acids.

3. Promote co-precipitation During alcohol-mediated nucleic acid purification, Poly A can form complexes with target nucleic acids for co-precipitation, which greatly enhances nucleic acid recovery rate.

Product Introduction

Product Name	Cat.No.	Specification	Storage Condition
Poly A Carrier RNA	HYC119	310 μg /100 mg/ 2 g	Store at -20℃ with a shelf life of 3 years

Product Name	Cat.No.	Specification	Storage Condition
Ribonuclease A (RNase A)	HYC115	100 mg /10 g/ 10g	Store at -20℃ with a shelf life of 3 years
Lysozyme	HYC121	1 g /5 g/ 100 g	Store at 2-8℃ with a shelf life of 1 years
Guanidine Thiocyanate	HYF321	Get a quote	Store at RT with a shelf life of 2 years
Guanidine hydrochloride	HYF322	Get a quote

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