Preclinical Data Marks First Poster Presentations on New Powerful & Precise Tmod™ CAR T and Start of BASECAMP-1 Study to Select Appropriate Patients

A2 Biotherapeutics, Inc., “A2 Bio”, is a biotechnology company focused on the development of a first-in-class Tmod™ T cell therapy platform to tackle the fundamental challenge in solid tumor treatment—the ability of cancer medicines to distinguish between tumor and normal cells.

A2 Bio today announced the first presentation of its Tmod™ platform; a powerful, precise targeting system controlled by tumor deletions which transforms CEA and MSLN CAR T cells into tumor-selective agents. Preclinical results demonstrate how Tmod™ primary T cells selectively kill tumor cells mixed with normal cells in vitro, and display robust activity in vivo. CEA Tmod™ cells selectively kill tumor cells within the same mouse implanted with established “normal” and tumor xenografts. MSLN Tmod™ constructs show similar selectivity, illustrating the breadth and modularity of the Tmod™ platform. Data are being featured on Nov. 13 at the Society for Immunotherapy of Cancer's (SITC) 36th Annual Meeting at the Walter E. Washington Convention Center in Washington, D.C.

“These data demonstrate some of the impressive properties of the Tmod™ system, and its potential to address a key obstacle to more effective cancer treatments: tumor vs. normal tissue selectivity,” said Alexander Kamb, Founder and Chief Scientific Officer of A2 Bio.

A2 Bio is also presenting a clinical trials poster on Nov 12, BASECAMP-1 (NCT04981119): An observational study to identify relapsed solid tumor patients with human leukocyte antigen (HLA) loss of heterozygosity (LOH). The study will use the Tempus xT-Onco Next Generation Sequencing diagnostic to identify patients with loss of HLA-A*02 heterozygosity. If eligible, these patients will be leukapheresed to bank T cells for subsequent autologous Tmod™ CAR T cell therapy at the time of relapse. BASECAMP-1 is currently recruiting patients with colorectal, pancreatic or non-small cell lung cancer at NYU Langone Medical Center, and will soon open at other cell therapy centers of excellence, including Mayo Clinic Rochester, UCLA Medical Center, UCSD Medical Center, and MD Anderson Cancer Center.

Diane Simeone, MD, Perlmutter Professor of Surgery at NYU who is a Principal Investigator stated, “BASECAMP-1 is an exciting study that is a potential game changer for relapsed patients after surgical resection with little viable treatment options. I am completely committed to helping to identify and enroll patients in this unique logic-gated CAR T immunotherapy.”

A2 Bio’s posters presented at SITC can be viewed on the company’s website at www.a2bio.com/science/abstracts-and-publications.

About A2 Biotherapeutics

A2 Biotherapeutics has invented the Tmod™ cell therapy platform to tackle the fundamental challenge in solid tumor treatment—the ability of cancer medicines to distinguish between tumor and normal cells. The Tmod™ mechanism utilizes two receptors to exploit common, specific gene losses in tumors which demarcate the tumor from normal cells. A2 is positioned to deliver a broad pipeline of both autologous and allogeneic cell products, with in-house cGMP manufacturing, a leadership team with 90+ years combined experience in biotech and cell therapy, and a world-class scientific advisory board. A2 is backed by investors that include The Column Group, Vida Ventures, Samsara BioCapital, Nextech Invest, Casdin Capital, Euclidean Capital, UC Investments (Office of the Chief Investment Officer of the Regents), Hartford HealthCare Endowment, StepStone Group, Schroders, Section 32 and Merck.

For more information, please visit www.a2bio.com and linkedin.com/a2-biotherapeutics.

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A2 Bio's Preclinical Data Marks First Poster Presentations on New Powerful & Precise Tmod™ CAR T and Start of BASECAMP-1 Study to Select Appropriate Patients