About Us

Laser Focus World is an industry bedrock—first published in 1965 and still going strong. We publish original articles about cutting-edge advances in lasers, optics, photonics, sensors, and quantum technologies, as well as test and measurement, and the shift currently underway to usher in the photonic integrated circuits, optical interconnects, and copackaged electronics and photonics to deliver the speed and efficiency essential for data centers of the future.

Our 80,000 qualified print subscribers—and 130,000 12-month engaged online audience—trust us to dive in and provide original journalism you won’t find elsewhere covering key emerging areas such as laser-driven inertial confinement fusion, lasers in space, integrated photonics, chipscale lasers, LiDAR, metasurfaces, high-energy laser weaponry, photonic crystals, and quantum computing/sensors/communications. We cover the innovations driving these markets.

Laser Focus World is part of Endeavor Business Media, a division of EndeavorB2B.

Laser Focus World Membership

Never miss any articles, videos, podcasts, or webinars by signing up for membership access to Laser Focus World online. You can manage your preferences all in one place—and provide our editorial team with your valued feedback.

Magazine Subscription

Can you subscribe to receive our print issue for free? Yes, you sure can!

Newsletter Subscription

A Laser Focus World newsletter subscription is free to qualified professionals:

The Daily Beam

Showcases the newest content from Laser Focus World, including photonics- and optics-based applications, components, research, and trends. (Daily)

Product Watch

The latest in products within the photonics industry. (9x per year)

Bio & Life Sciences Product Watch

The latest in products within the biophotonics industry. (4x per year)

Laser Processing Product Watch

The latest in products within the laser processing industry. (3x per year)

Get Published!

If you’d like to write an article for us, reach out with a short pitch to Sally Cole Johnson: [email protected]. We love to hear from you.

Photonics Hot List

Laser Focus World produces a video newscast that gives a peek into what’s happening in the world of photonics.

Following the Photons: A Photonics Podcast

Following the Photons: A Photonics Podcast dives deep into the fascinating world of photonics. Our weekly episodes feature interviews and discussions with industry and research experts, providing valuable perspectives on the issues, technologies, and trends shaping the photonics community.

Social Media

Bluesky • Facebook • Instagram • LinkedIn • YouTube

Meet the Laser Focus World Team

Editorial

Sales

Editorial Advisory Board

  • Professor Andrea M. Armani, University of Southern California
  • Ruti Ben-Shlomi, Ph.D., LightSolver
  • James Butler, Ph.D., Hamamatsu
  • Natalie Fardian-Melamed, Ph.D., Columbia University
  • Justin Sigley, Ph.D., AmeriCOM
  • Professor Birgit Stiller, Max Planck Institute for the Science of Light, and Leibniz University of Hannover
  • Professor Stephen Sweeney, University of Glasgow
  • Mohan Wang, Ph.D., University of Oxford
  • Professor Xuchen Wang, Harbin Engineering University
  • Professor Stefan Witte, Delft University of Technology
My Watchlist
Indicators
Industrial Laser Index
Markets
Stocks
ETFs
Tools
Markets:
Overview
News
Currencies
International
Treasuries

Geron (NASDAQ: GERN) Reports Positive Results From IMerge Phase 3 Trial of Imetelstat for Lower Risk MDS

By: Spotlight Growth

Geron Corporation (NASDAQ: GERN) is engaged as a late-stage biopharmaceutical company, which is focused on the research and development of treatments for patients suffering from hematologic malignancies. Shares of the late-stage biopharma company are rallying 37% through early trading on Wednesday, January 4, 2023. Over the past three months, Geron has seen average daily volume of 3.99 million shares. However, volume of 94.41 million shares or dollar volume of around $311.55 million, has already exchanged hands through early trading.

Shares of Geron are gaining after the company reported positive top-line and secondary endpoint results from its IMerge Phase 3 clinical trial of Imetelstat for the treatment of lower risk myelodysplastic syndromes (MDS) who have relapsed, refractory or are not eligible for erythropoiesis stimulating agents (ESAs).

The IMerge Phase 3 trial was a double-blind, 2:1 randomized, placebo-controlled clinical trial. During the trial’s first 8 weeks, patients treated with Imetelstat saw very statistically significant improvements compared to the placebo group. After eight weeks, Imetelstat patients saw a transfusion independence (TI) reading of 47 compared to 9 in the placebo group. This met the primary endpoints for the Phase 3 trial. Over a 24-week period, Imetelstat patients saw a TI reading of 33, compared to the placebo group’s 2 result.

This shows that Imetelstat-treated patients were able to achieve transfusion independent broadly among lower risk MDS subtypes. Average hemoglobin levels in Imetelstat patients saw a robust increase over time compared to the placebo group. In additional, test groups saw clinically-meaningful average reduction in RBC transfusion units compared to the placebo group.

Imetelstat maintained a very strong safety profile throughout the clinical trial. Treatment emergent adverse events (TEAEs) that were seen in the IMerge Phase 3 trial were consistent with the known potential safety risks of the treatment. No new safety issues were found.

Moving forward, Geron Corporation says it plans to submit a New Drug Application with the U.S. Food and Drug Administration, as well as a Marketing Authorization Application (MAA) with EU regulators during the second half of 2023. Geron estimates commcerical launch of Imetelstat to take place sometime during the first half of 2024 in the U.S. and by the end of 2024 in the EU.

“Today is a great day for lower risk MDS patients who are living with the burden of transfusions. The results from the IMerge Phase 3 study were resoundingly positive, presenting compelling durability of transfusion independence, delivering on the promise of imetelstat and telomerase inhibition for these patients,” said John A. Scarlett, M.D., Geron’s Chairman and Chief Executive Officer. “This milestone is the first of many upcoming catalysts for Geron, with planned U.S. and EU regulatory submissions in 2023, as well as preparations for a potential U.S. commercial launch. In addition, in 2024, we expect an interim analysis of the IMpactMF Phase 3 trial of imetelstat in relapsed/refractory myelofibrosis.”

Disclosure: No position. Spotlight Growth has no relationships with any of the companies mentioned in this article and did not receive payment in any form for its creation. This is an opinion article and is not meant to be financial advise. We are not broker-dealers or investment professionals. Please conduct your own due diligence. For more information on our disclosures, please visit: https://spotlightgrowth.com/disclosures/

The post Geron (NASDAQ: GERN) Reports Positive Results From IMerge Phase 3 Trial of Imetelstat for Lower Risk MDS appeared first on Spotlight Growth.

More News

View More
PayPal Stock: Why Wall Street May Be Undervaluing This Giant
Via MarketBeat
Topics Economy
Tickers PYPL
Why Vertical Aerospace Could Lead the eVTOL Market by 2028
Via MarketBeat
Tickers EVTL VTOL
Is Draganfly's Army Partnership a Game-Changer for Investors?
Via MarketBeat
Tickers DPRO
3 Auto Stocks to Watch as EV and Hybrid Demand Shifts
Via MarketBeat
Topics Economy Stocks World Trade
Tickers F GM TSLA
4 Stocks Set to Benefit From the PDT Rule Change
Via MarketBeat
Topics Regulatory Compliance
Tickers HOOD IBKR SCHW TSLA
Stock Quote API & Stock News API supplied by www.cloudquote.io
Quotes delayed at least 20 minutes.
By accessing this page, you agree to the following
Privacy Policy and Terms Of Service.